Haematologica 2003 - Supplements

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fractures has been applied to multiple myeloma. This investigation tests the hypothesis that kyphoplasty can significantly restore vertebral height and spinal function. Eighteen consecutive patients with vertebral fractured secondary to multiple myeloma underwent kyphoplasty balloon reduction and stabilization with PMMA. Patients were evaluated prior to treatment and post-operatively with the validated general Oswestry back questionnaire. 7 patients with 20 fractures were measured for height restoration on long kyphosis (36 inch) standing films. Over 90% of the fractures were older than 3 months by history and MRI. By Oswestry analysis the average pre-op score was 48.94 and the average post-op score 32.70 with and average improvement of 16.23 (p
those with Hb >13 g/dL. Analysis of covariance showed that this relationship was not explained by the effect of covariates. A higher correlation with Hb was observed for the FACT-An Fatigue subscale than for the non-fatigue items (Spearman r=0.277, P=.0001 vs 0.214, P=.0001, respectively). FACT-An scores were significantly lower in older patients, particularly older women (from 62.0 if ≤50 yrs to 51.2 if >70 yrs for women vs 60.5 to 56.3 for men, respectively); in patients with no response or in relapse (50.1 vs remission 58.3); and in patients with concurrent disease (52.7 vs 58.7 without concurrent disease). The differences between the subgroups in Hb level and other covariates partially explained these effects. After adjusting for Hb and other covariates (yes 56.8, no 55.9) the effect of concomitant chemotherapy (yes 58.3, no 53.5) was no longer significant.). In this large study population we demonstrate a significant correlation between fatigue and Hb level in MM patients. Hemoglobin level appears to play an important role in determining some aspects of QOL. The treatment of anemia should be a consideration in the global management of patients with MM. 253 In multiple myeloma, the extent of skeletal disease and response to therapy are more important predictors for quality of life than hemoglobin levels Finn Wisløff1, Nina Gulbrandsen1, Martin Hjorth2, Stig Lenhoff3 For the Nordic Myeloma Study Group (NMSG). 1Ulleval University Hospital, OslO, Norway; 2Lidkoping Hospital, Lidkoping and 3Lund University Hospital, Lund, Sweden Prospective trials have demonstrated a statistically significant effect of erythropoietin treatment on Hb levels and quality-of-life (QoL) in the anaemia of malignant disease. However, the effect on QoL scores seems to be modest. In order to explore the relationship between Hb and QoL, we pooled data from 745 patients taking part in two recent NMSG trials (4/90 and 5/94) who had completed the QoL questionnaire EORTC QLQ-C30 prior to treatment and at regular intervals during follow-up. By means of this questionnaire, several QoL domains, e.g. physical functioning, global quality of life, fatigue, pain and dyspnea, were assessed by a 0-100 scale where differences of 5-10 are considered small, 11-20 moderate and above 20 large. QoL scores at diagnosis were outcome variables in linear regression analysis, with Hb, age, gender, Durie & Salmon stage, extent of skeletal disease, beta2-microglobulin, creatinine, calcium and albumin as predictor variables. At 12 months of follow-up, the effect of Hb on QoL scores was adjusted for age, gender and the degree of response to therapy (complete, partial or minor response, no response or progressive/relapsed disease). P-values < 0.01 were required for statistical significance. In univariate analysis of data obtained at baseline, Hb was significantly related only to fatigue (p
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Focussed Symposia Arsenic trioxide
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assess whether such a program will
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The overall response rate was noted
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Figure 5A Table 1: VEL + THAL for R
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naturally occurring OPG. Present tr
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0.505). Finally, the multiple event
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CLINICOPATHOLOGICAL DEFINITION OF W
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Plenary Sessions 1. Development of
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clonotypic IgH VDJ signature confir
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can be considered as two entities,
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immunofluorescence staining for DKK
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P2.3 DEVELOPMENT OF A MULTIPLE MYEL
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P2.5 MOLECULAR CYTOGENETICS OF MYEL
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clear that the biggest challenge fo
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esponse and have demonstrated that
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variable region of the idiotypic im
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4. From MGUS to symptomatic MM Fig.
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(MRI); some have claimed that level
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P4.5 CYTOKINES IN MGUS: THERAPEUTIC
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preventing phosphorylation of p70S6
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transducing component of the interl
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survive initial drug exposure and a
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quiescent counterpart, the human um
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transcriptional activity of NF-êB;
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manifestations and anomalous protei
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P7.4 ROLE OF SERUM FREE LIGHT CHAIN
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P7.6 IMMUNOPHENOTYPIC INVESTIGATION
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presumably through the circulation,
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9. Chemotherapy, maintenance treatm
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stratified according to their antim
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explore higher doses of zoledronic
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initial therapy. However, the role
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P10.2.2 SINGLE VERSUS TANDEM HIGH D
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With a median follow-up of 38 month
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cells could be harvested following
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11. What is the role of allogeneic
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found that 75% of patients who were
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patients with responsive disease 3
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9. Giralt S, Estey E, Albitar M, et
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Badros A, Barlogie B, Siegel E, et
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Figure 3b. Event-free Survival 4-Ye
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improve patient outcome in MM. Impo
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myeloma and in 40% of previously un
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degrade OPG in the same way as myel
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P12.2.5 MONOCLONAL ANTIBODY THERAPY
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myeloma. Blood 2001; 98:210-216. 6.
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MHC molecules, in effectively prese
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mice demonstrate that class II-spec
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detected in 293 and NIH3T3 cells. S
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hypothesis that (1) CCND1 and FGFR3
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patient samples. In addition, the p
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016 NEUTRAL ENDOPEPTIDASE (CD10) KN
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2. Genetic heterogeneity in MM: imp
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evidence from two t(11;14) cases wh
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immunoglobulin heavy chain (IgH) lo
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034 Instability of Pericentromeric
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clusters were found, the first was
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MGUS but most likely not crucial fo
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Objective: To compare the impact on
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4 patients had MMSET/IgH but did no
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and clonal PC from MGUS, MM and PCL
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059 VEGF receptor expresion in Mult
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two HLA-A2+ myeloma patients with C
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molecules expressed on the surface
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Recognition of these antigens appea
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Diagnosis requires a single area of
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081 Incidence of solid tumors in co
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Growth Factor (VEGF), Hepatocyte Gr
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PC-AI levels of MGUS and SMM patien
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093 The predominant pathway of tran
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was associated with I.V. line, whil
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103 Vascular amyloidosis induces se
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5. Signal transduction pathways and
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integrin in IGF-1-triggered MM cell
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118 IL-6- Induced Phosphorylation o
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123 THE IGF/IGF-1R SYSTEM IS A MAJO
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human myeloma cell line (HMCL) to a
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ligation or dexamethasone (Georgii-
Page 157 and 158: 6. Role of microenvironment 6.1 Cel
Page 159 and 160: 141 Human myeloma cells adhere to f
Page 161 and 162: 145 STUDY OF BONE MARROW ANGIOGENES
Page 163 and 164: patients, the growth of primary mye
Page 165 and 166: tibia (con=49.1±0.7mg/cm2 vs 5T2=4
Page 167 and 168: 157 The Nitrogen-Containing Bisphos
Page 169 and 170: 7. New prognostic criteria for clas
Page 171 and 172: atio of >3. This system has subdivi
Page 173 and 174: Patient 1 (IgG/κ);IgG - 16.5 days,
Page 175 and 176: 176 Pro-inflammatory and angiogenic
Page 177 and 178: 180 Clinical study on the bone lesi
Page 179 and 180: 7.2 Imaging studies 185 99mTc-MIBI
Page 181 and 182: 189 Factors Predicting Occult Spina
Page 183 and 184: vivo detected resonances was invest
Page 185 and 186: Support Unit (CTSU) with flexibilit
Page 187 and 188: (β2m) & C reactive protein (CRP).
Page 189 and 190: plasmids carrying the clonotypic in
Page 191 and 192: newly diagnosed multiple myeloma as
Page 193 and 194: 216 Transgenic expression of Myc an
Page 195 and 196: 221 Prolonged survival in the 5T2MM
Page 197 and 198: 9. Chemotherapy, maintenance, treat
Page 199 and 200: 229 EFFECTIVENESS OF STANDARD CHEMO
Page 201 and 202: 234 Melphalan and Dexamethasone- Is
Page 203 and 204: Methods. We investigated the VECD p
Page 205 and 206: 9.2 Renal complications. 243 MERIT
Page 207: cost of SRE-related care was $10,24
Page 211 and 212: sustained response, lasting from 52
Page 213 and 214: proportion of bone abnormality. IgD
Page 215 and 216: disease. The lack of response to in
Page 217 and 218: yielding a median of 3x106/kg CD34
Page 219 and 220: patients(pts) aged ≥60 yrs. We co
Page 221 and 222: PBSC mobilizing regimen utilizing C
Page 223 and 224: their leukocytes and platelets. No
Page 225 and 226: 25 Gy to marrow. The tracer dose wa
Page 227 and 228: non-CR after the first transplant a
Page 229 and 230: 296 PERIPHERAL BLOOD STEM CELL TRAN
Page 231 and 232: References Effect of dose-intensive
Page 233 and 234: with cyclosporine A and methotrexat
Page 235 and 236: 11.Role of novel therapies targetin
Page 237 and 238: 312 Thalidomide as Rescue of Relaps
Page 239 and 240: patients, light chain in 1 patients
Page 241 and 242: platelets of 207 (76-402), B2M of 3
Page 243 and 244: 325 Low Dose Thalidomide plus Dexam
Page 245 and 246: in 5 pts (11%), M protein decreased
Page 247 and 248: time from diagnosis was 3.7 years a
Page 249 and 250: 339 Thalidomide, Clarithromycin and
Page 251 and 252: 344 COMBINATION OF THALIDOMIDE, DEX
Page 253 and 254: experienced early death during the
Page 255 and 256: untreated patients with high tumor
Page 257 and 258: 357 Thalidomide protects endothelia
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362 EOSINOPHILIA IS A VERY COMMON F
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11.5 CC 4047, PS 341 and arsenic tr
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without chromosome 13. Mean IC50 fo
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myeloma patients. Phase I data indi
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11.6 Other drugs 380 EFFECT OF STI5
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significant inhibition of cell prol
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which acts to prevent the synthesis
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of B and its metabolites, however,
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and 10 months after start of therap
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terminal kinase (JNK) pathway which
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lymphocytes was tested by Ellispot.
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411 Dendritic Cell-Based Idiotype V
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Author Index Abe M 74 160 Abelman W
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De La Serna J 291 De Laurenzi A P11
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Hull DR 338 Hullen C P10.2.1 Humes
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Morra E 249 280 359 Morris CM 226 M
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Siegel D 70 115 250 Sierra J 304 30
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