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Research Updates - Homeopathy 

A monthly research e-newsletter by www.audesapere.in 

ISSN 2278–4500 

Volume 1 Issue: 07 | July 2012 | Page – 23 – 32 

Chief Editor: Dr. Saurav Arora 

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From the Editors Desk 

Featured Article 

Research Studies linked 

Review articles-Editorial 

Research methodology: Useful links 

News 

Upcoming Events 

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Browse www.audesapere.in/researchupdates for electronic version of this e-newsletter | 23

From the Editor’s Desk 

Dear Reader, 

Once again the latest issue of Research Updates-Homeopathy is in front of you, for your comments and 

contributions. This issue is a special one as it will witness one important announcement. This e-newsletter has got its 

unique International Standard Serial Number – ISSN from this issue onwards, which will make indexing and quoting 

easier for contributors and libraries. Besides such great news, you will also come across a new section, “Veterinary 

Homeopathy” nested under “Research studies – Database”, which will index studies published in veterinary practices 

in homeopathy. 

I am also happy to announce that the Blogs Section is now “Research publishing platform” for homeopathic 

researchers and practitioners. It has been redesigned, keeping basic division of research as sections, so that the 

readers can contribute their articles on homeopathic research with ease. The articles may range from literary 

research to clinical and fundamental research. The articles will also be featured in e-newsletter issues for wider 

circulation and interaction. To start with, a Book Review on a compilation (literary research) has been placed in this 

issue along with other regular sections like Research studies indexed, Review articles, Research methodology-Useful 

links, News, Upcoming events etc. 

Therefore, it is requested to extend your kind expertise and contribute some of your articles for promotion 

of scientific research in homeopathy. 

This month onwards this portal will start including some of the key open access articles published in 

homeopathy along with regular indexing of peer reviewed published studies. I hope to have your constant support 

as always. Your support can take homeopathy to newer heights. 

Happy reading! 

Dr. Saurav Arora 


Featured Article 

Book Review 

Keynotes Materia Medica Volume –I 

Keynote prescription has been an indispensable part of our homeopathic practice since inception. The concept is as 

long as homeopathy, but was given a boost by H. C. Allen, to whom we must pay our gratitude. Keynotes play a major role in 

our day to day practice. Almost every other day we hear senior physicians suggesting us to go through Keynotes every day to 

flourish our practice to newer heights. Practicing Keynotes is like an art which must be followed by heart. 

To keep the spirit of Keynotes high and with aim to update them, Central Council for Research in Homoeopathy (CCRH) 

has undertaken an initiative to compile Keynotes Materia Medica from authentic sources. The book is a work of dedication 

added to ever growing sea of materia medicas, being authentic and simple. The salient information regarding the book can be 

summarized as: - 

Name of Book: Keynotes of the Homoeopathic Materia Medica 

Volume: I 

Drug compiled: 25 

Author information: 

• Chief Editor: Dr. Chaturbuja Nayak 

• Editor: Dr. Chinta Raveendar 

• Assistant Editor: Dr. Debadatta Nayak 

• Expert Committee: 

‣ Prof. (Dr.) S. K. Bhattarcharya 

‣ Prof. (Dr.). L. K. Nanda 

‣ Dr. V. K. Chauhan 

‣ Dr. S. Praveen Kumar 

‣ Dr. Ajit Kulkarni 

‣ Dr. Asha Chowdhry 


Printed and published by: Central Council for Research in Homoeopathy (CCRH), an autonomous Organization 

under Ministry of Health and Family Welfare, Deptt of AYUSH, Govt. of India, 61-65, Institutional area, Opp. D 

Block, Janak Puri, New Dehli 110058. Tel: 011-28525533, Fax: 011-28521060. Email: ccrh@del3.vsnl.net.in. 

Website: www.ccrhindia.org 

ISBN Status: 978-81-920840-5-3 

Copyright status: Copyright with CCRH 

Price: 120/- INR 

Availability status: Yes, available at CCRH Headquarters, can be ordered by post. 

In the present work author(s) have expressed the need to have an updated version of existing keynote materia medica, as 

there are various instances where practitioners report ambiguity, spelling mistakes, improper arrangements of symptoms etc. 

Moreover, there are certain concepts/old terms which are obsolete now days. This is need of the hour to update such 

information for our own knowledge sake and evolution. The compilation has beautifully collected keynotes, keeping “Keynotes 

by HC Allen” as base and addition of keynotes from authentic source books like - Hering’s Guiding Symptoms of our Materia 

Medica, Hahnemann’s Materia Medica Pura, J. H. Clarke’s dictionary of Practical Materia Medica and Pocket manual of 

Homoeopathic Materia Medica by William Boericke. It is worth mentioning here that no additions from any experience, 

verification or by other means have been included in this book. Therefore, this book is a pure compilation of keynotes from 

authentic source books, and may aptly be called keynote pura. 

In addition to compilation, authors have given some interesting and useful sections loaded with information from 

various sources. Basic information about drug such as botanical/chemical name, source, part(s) used, habitat, 

constituents/molecular formula, etc., followed by an introduction, are some of the new headings you will discover in this book. 

Here also, the information is primarily derived from Homoeopathic Pharmacopoeia of India (HPI). The source of information if 

other than HPI is mentioned in the footnote of remedy. The keynotes are supplemented with keywords, sphere of action, 

makeup of the remedy, ailments from and guiding features which make this materia medica handy and informative from the 

first line itself. The schema of each remedy is placed as per Generals (Mental and Physical) followed by Particulars (arranged as 

per systems of the body). Care has been taken to replace old terms with latest ones, but some old terms are kept owing to their 

historical value associated with homeopathy. 

The book has compiled drugs according to the official syllabus for 1st professional year of undergraduate students of 

homeopathy in India endorsed by Central Council of Homoeopathy. This limits the number of drugs compiled to 25 only in 

volume – I. This work will be carried on to volume - IV, keeping in view the syllabus of 2 nd , 3 rd and 4 th BHMS. This fact may be 

considered as one of the minor drawback of this compilation. Since such a compilation will come periodically with limited 

number of drugs, readers would have to wait more for such handy and authentic book. It is sincerely hoped that authors might 

consider publishing more number of remedies (beyond recommended for this book) in one or two handy volumes, for the 

benefit of profession. 

All in all, this book is a good and handy compilation of keynotes for both practitioners and students. You can also give 

your feedback to above review at http://audesapere.in/blogs/?p=724 


http://audesapere.in/blogs/?p=724 

Research studies linked 

Fundamental/Basic research 

www.audesapere.in/researchstudies/fr.html 

Effect of Homeopathic Medicines on Transplanted Tumors 

in Mice. ES Sunila, Girija Kuttan, Preethi KC, Ramadasan 

Kuttan, Asian Pacific J Cancer Prev, 8, 390-394, 2007 

Abstract 

Ultra low doses used in homeopathic medicines are 

reported to have healing potential for various diseases but 

their action remains controversial. In this study we have 

investigated the antitumour and antimetastatic activity of 

selected homeopathic medicines against transplanted 

tumours in mice. It was found that Ruta graveolens 200c 

and Hydrastis canadensis 200c significantly increased the 

lifespan of Ehrlich Ascites Carcinoma and Dalton's 

Lymphoma Ascites induced tumour-bearing animals by 

49.7%, and 69.4% respectively. Moreover there was 95.6% 

and 95.8% reduction of solid tumour volume in Ruta 200c 

and Hydrastis 200c treated animals on the 31st day after 

tumour inoculation. Hydrastis 1M given orally significantly 

inhibited the growth of developed solid tumours produced 

by DLA cells and increased the lifespan of tumour bearing 

animals. Some 9 out of 15 animals with developed tumors 

were completely tumour free after treatment with 

Hydrastis 1M. Significant anti-metastatic activity was also 

found in B16F-10 melanoma-bearing animals treated with 

Thuja1M, Hydrastis 1M and Lycopodium1M. This was 

evident from the inhibition of lung tumour nodule 

formation, morphological and histopathological analysis of 

lung and decreased levels of γ-GT in serum, a cellular 

marker of proliferation. These findings support that 

homeopathic preparations of Ruta and Hydrastis have 

significant antitumour activity. The mechanism of action of 

these medicines is not known at present. 

Key words: Alternative medicine - homeopathy - hydrastis – 

lycopodium - melanoma - metastasis - ruta - thuja 

Inhibition of Chemically Induced Carcinogenesis by Drugs 

Used in Homeopathic Medicine. K B Hari Kumar, E.S. Sunila, 

Girija Kuttan, K C Preethi, C Nimita Venugopal, Ramadasan 

Kuttan*. Asian Pacific J Cancer Prev, 8, 98-102 | 2007 

Abstract 

Homeopathy is considered as one modality for cancer 

therapy. However, there are only very few clinical reports 

on the activity of the drugs, as well as in experimental 

animals. Presently we have evaluated the inhibitor effects 

of potentized homeopathic preparations against N'- 

nitrosodiethylamine (NDEA) induced hepatocellular 

carcinoma in rats as well as 3-methylcholanthrene-induced 

sarcomas in mice. We have used Ruta, Hydrastis, 

Lycopodium and Thuja, which are commonly employed in 

homeopathy for treating cancer. Administration of NDEA in 

rats resulted in tumor induction in the liver and elevated 

marker enzymes such as gamma-glutamyl transpeptidase, 

glutamate pyruvate transaminase, glutamate oxaloacetate 

transaminase and alkaline phosphatase in the serum and in 

liver. Concomitant administration of homeopathic drugs 

retarded the tumor growth and significantly reduced the 

elevated marker enzymes level as revealed by 

morphological, biochemical and histopathological 

evaluation. Out of the four drugs studied, Ruta 200c 

showed maximum inhibition of liver tumor development. 

Ruta 200c and phosphorus 1M were found to reduce the 

incidence of 3-methylcholanthreneinduced sarcomas and 

also increase the life span of mice harboring the tumours. 

These studies demonstrate that homeopathic drugs, at 

ultra low doses, may be able to decrease tumor induction 

by carcinogen administration. At present we do not know 

the mechanisms of action of these drugs useful against 

carcinogenesis. 

Key Words: N'-Nitrosodiethylamine - hepatocellular 

carcinoma - sarcoma - homeopathy - Ruta - Thuja - 

Hydrastis- Lycopodium- phosphorus 


Applied Research 

http://www.audesapere.in/researchstudies/app.html 

Use of biotherapic in the control of natural infestation 

by Boophilus microplus: pilot study 

Nilceu Lemos Silva et al 

Int J High Dilution Res 2008; 7(22): 36-38 

ABSTRACT 

In the control of tick-borne disease (TBD), resistance to 

chemical products has been reported and a concern with 

the preservation of the environment requires alternative 

procedures to control infestation by Boophilus microplus 

worldwide. The use of biotherapic preparations is one of 

such alternatives. The aim of this study was to evaluate the 

effects of a biotherapic mixture including B. microplus in 

naturally infested cattle. 27 animals were divided in 3 

groups (n=9): I – control, received no treatment; II- treated 

with amitraz dip; III- treated with a standard commercial 

mixture of biotherapic 12CH, p.o. Group III presented a 

statistically significant decrease of ticks when compared to 

the control group (p

SUBJECTS: A total of 119 patients with vertigo of various 

origins (from whom 105 patients could be analyzed as 

intended per protocol). 

MAIN OUTCOME MEASURES: Frequency, duration, and 

intensity of vertigo attacks. 

RESULTS: Both homeopathic and conventional treatments 

showed a clinically relevant reduction in the mean 

frequency, duration, and intensity of the vertigo attacks. 

The therapeutic equivalence of the homeopathic remedy 

and betahistine was established statistically. 

CONCLUSIONS: Concerning the main efficacy variable, 

therapeutic equivalence between the homeopathic remedy 

and betahistine could be shown with statistical significance 

(confirmative analysis). Both remedies reduced the 

frequency, duration, and intensity of vertigo attacks during 

a 6-week treatment period. 

Also, vertigo-specific complaints were significantly reduced 

in both treatment groups. 

Effective treatment of seborrheic dermatitis using a low 

dose, oral homeopathic medication consisting of 

potassium bromide, sodium bromide, nickel sulfate, and 

sodium chloride in a double-blind, placebo-controlled 

study. 

Smith SA, Baker AE, Williams JH. Altern Med Rev. 2002 

Feb;7(1):59-67. 

BACKGROUND: Topical over-the-counter remedies exist to 

aid in the control of seborrheic dermatitis and chronic 

dandruff on a superficial level. Low-dose systemic oral 

nickel and bromide therapy has shown promise in providing 

improvement and eventual clearing of the disease. 

OBJECTIVE: The purpose of this study was to further 

evaluate the effect of an orally administered low-dose, 

homeopathic mineral therapy (Potassium bromide 1X, 

Sodium bromide 2X, Nickel sulfate 3X, Sodium chloride 6X) 

on seborrheic dermatitis and chronic dandruff. 

METHODS: Forty-one patients with seborrheic dermatitis 

and/or chronic dandruff were assigned to one of two 

treatment groups: Active (containing the medication) or 

placebo (vehicle). Study medication was administered in a 

placebo-controlled, randomly-selected, double-blind study 

for 10 weeks. At the end of 10 weeks all patients crossed 

over to the active medication, under a different label for an 

additional 10 weeks in an open study format. 

RESULTS: Twenty-nine patients completed the 10-week 

blinded portion of the study. After 10 weeks of treatment, 

the disease state of the active patients improved 

significantly over that of the placebo patients (p

contributing to its immense popularity in Kolkata. Whether 

this can be translated into a willingness to use similar 

natural compounds for cancer prevention and treatment 

purposes now needs to be analysed. 

Key Words: Awareness - alternative cancer therapy – 

homeopathy – India 

HPT/Drug Standardization 

http://www.audesapere.in/researchstudies/hpt.html 

Evaluation of Hepatoprotective Effect of Leaves of Cassia 

sophera Linn, Evidence-Based Complementary and 

Alternative Medicine | Volume 2012, Article ID 436139 | 

Open Access 

In the present study, the hepato-protective activity of 

ethanolic extracts of Cassia sophera Linn. leaves was 

evaluated against carbon-tetrachloride- (CCl4-) induced 

hepatic damage in rats. The extracts at doses of 200 and 

400 mg/kg were administered orally once daily. The 

hepatoprotection was assessed in terms of reduction in 

histological damage, changes in serum enzymes, serum 

glutamate oxaloacetate transaminase (AST), serum 

glutamate pyruvate transaminase (ALT), serum alkaline 

phosphatase (ALP), total bilirubin, and total protein levels. 

The substantially elevated serum enzymatic levels of AST, 

ALT, ALP, and total bilirubin were restored towards the 

normalization significantly by the extracts. The decreased 

serum total protein level was significantly normalized. 

Silymarin was used as standard reference and exhibited 

significant hepato-protective activity against carbon 

tetrachloride-induced hepatotoxicity in rats. The 

biochemical observations were supplemented with 

histopathological examination of rat liver sections. The 

results of this study strongly indicate that Cassia sophera 

leaves have potent hepato-protective action against carbon 

tetrachloride-induced hepatic damage in rats. This study 

suggests that possible activity may be due to the presence 

of flavonoids in the extracts. 

Anti-inflammatory activity of flower extract of Calendula 

officinalis Linn. and its possible mechanism of action 

Preethi KC, Kuttan G, Kuttan R. Indian J Exp Biol. 2009 

Feb;47(2):113-20. 

Abstract 

Calendula officinalis flower extract possessed significant 

anti-inflammatory activity against carrageenan and dextraninduced 

acute paw edema. Oral administration of 250 and 

500 mg/kg body weight Calendula extract produced 

significant inhibition (50.6 and 65.9% respectively) in paw 

edema of animals induced by carrageenan and 41.9 and 

42.4% respectively with inflammation produced by dextran. 

In chronic anti-inflammatory model using formalin, 

administration of 250 and 500 mg/kg body weight 

Calendula extract produced an inhibition of 32.9 and 62.3% 

respectively compared to controls. TNF-alpha production 

by macrophage culture treated with lipopolysaccharide 

(LPS) was found to be significantly inhibited by Calendula 

extract. Moreover, increased levels of proinflammatory 

cytokines IL- 1beta, IL-6, TNF-alpha and IFN-gamma and 

acute phase protein, C- reactive protein (CRP) in mice 

produced by LPS injection were inhibited significantly by 

the extract. LPS induced cyclooxygenase-2 (Cox-2) levels in 

mice spleen were also found to be inhibited by extract 

treatment. The results showed that potent antiinflammatory 

response of C. officinalis extract may be 

mediated by the inhibition of proinflammatory cytokines 

and Cox-2 and subsequent prostaglandin synthesis. 

Veterinary Homeopathy 

www.audesapere.in/researchstudies/vet.html 

Preliminary study of homeopathic treatment of subclinical 

mastitis evaluated through somatic cells count and 

California mastitis test 

Carlos Dias et al 

Int J High Dilution Res 2008; 7(24): 147-151 

ABSTRACT 

The present paper presents the results of homeopathic 

treatment of 25 Holstein breed cows aged 3 to 8 years old 

diagnosed with subclinical mastitis through California 

Mastitis Test (CMT). Animals were divided into 3 groups 

according with infection level. A homeopathic complex was 

developed on the grounds of clinical aspects, including 

Phosphorus 30x, Phytolacca 30x, Silicea 30x, Sulphur 30x, 

Belladona 30x, Bryonia alba 30x, Pulsatilla 30x, Calendula 

30x and biotherapic of Staphylococcus aureus 200x. The 

remedy was added to salt and was administered to cattle 

100g/cow/day for 75 days. CMT were carried out every 2 


weeks to control incidence and severity of mastitis; somatic 

cells count (SCC) was performed at the beginning and the 

end of treatment. CMT showed significant improvement in 

regression of infection level all throughout the study; final 

SCC showed decrease in 82% of animals, signaling thus 

efficacy of the homeopathic treatment. 

Keywords: Subclinical mastitis; Dairy cows; Homeopathy; 

California Mastitis Test, Somatic Cells Count. 

Homeopathic treatment of vaginal leiomyoma in a dog: 

case report. 

Maria Ignez Carvalho Ferreira(MSc), Luiz Figueira Pinto 

(PhD) 

Int J High Dilution Res 2008; 7(24):152-158 

ABSTRACT 

The most common vaginal neoplasias in old dogs are 

leiomyoma and fibroma. Although surgical excision is the 

indicated treatment, it does not eliminate potential 

complications that may lead to death or poor quality of life. 

This paper reports the case of a 9 year-old female 

Doberman dog with vaginal leiomyoma attended by 

copious and recidivating colporrhagia homeopathically 

treated between March and December 2005. Homeopathic 

approach was the one designed at Homeopathic Unit of 

the Veterinary Hospital, Rural Federal University of Rio de 

Janeiro, Brazil. The progress of disease was assessed 

through clinical evaluation, laboratory exams and 

ultrasonography. Hemorrhage decreased while the general 

clinical state of the animal improved. After 7 months of 

homeopathic treatment, the tumor was spontaneously 

eliminated through violent abdominal contractions, which 

was followed by recovery of the animal's state of health. 

Keywords: Homeopathy; Veterinary medicine; Tumors; 

Leiomyoma; Vaginal; Dogs 

Background: A method for assessing the model validity of 

Randomised controlled trials of homeopathy is needed. To 

date, only conventional standards for assessing intrinsic 

bias (internal validity) of trials have been invoked, with little 

recognition of the special characteristics of homeopathy. 

We aimed to identify relevant judgmental domains to use in 

assessing the model validity of homeopathic treatment 

(MVHT). We define MVHT as the extent to which a 

homeopathic intervention and the main measure of its 

outcome, as implemented in a randomized controlled trial 

(RCT), reflect 'state-of-the-art' homeopathic practice. 

Methods: Using an iterative process, an international group 

of experts developed a set of six judgmental domains, with 

associated descriptive criteria. The domains address: (I) the 

rationale for the choice of the particular homeopathic 

intervention; (II) the homeopathic principles reflected in 

the intervention; (III) the extent of homeopathic 

practitioner input; (IV) the nature of the main outcome 

measure; (V) the capability of the main outcome measure 

to detect change; (VI) the length of follow-up to the 

endpoint of the study. Six papers reporting RCTs of 

homeopathy of varying design were randomly selected 

from the literature. A standard form was used to record 

each assessor's independent response per domain, using 

the optional verdicts 'Yes', 'Unclear', 'No'. Concordance 

among the eight verdicts per domain, across all six papers, 

was evaluated using the kappa (kappa) statistic. 

Results: The six judgmental domains enabled MVHT to be 

assessed with 'fair' to 'almost perfect' concordance in each 

case. For the six RCTs examined, the method allowed 

MVHT to be classified overall as 'acceptable' in three, 

'unclear' in two, and 'inadequate' in one. 

Conclusion: Future systematic reviews of RCTs in 

homeopathy should adopt the MVHT method as part of a 

complete appraisal of trial validity. 

Review articles-Editorial 

www.audesapere.in/reviewarticles 

Method for appraising model validity of randomised 

controlled trials of homeopathic treatment: multi-rater 

concordance study, BMC Medical Research Methodology 

2012 

Research methodology: useful Links 

Method for appraising model validity of 

randomised controlled trials of homeopathic 

treatment: multi-rater concordance study 

Series on Evaluation of Scientific Publications 

Browse www.audesapere.in/researchupdates for electronic version of this e-newsletter | 31 

o 

Part - I: Critical Appraisal of Scientific Articles

o 

o 

o 

Part - II: Study design in medical research 

Part - III: Types of Study in Medical Research 

Part - IV: Confidence interval or p-value 

o Part -V: Requirements and Assessment of 

Laboratory Tests 

News 

Govt. of India grant for research in Homoeopathy – apply now 

Time to act now! 

A critique of the Swiss report Homeopathy in 

Healthcare by Edzard Ernst 

The Swiss report on homeopathy: a case study of 

research misconduct by David Martin Shaw 

Why Liquid Water Probably Does Not "Remember" 

Bier Martin 

 

 

Upcoming Events 

A Leap To The Simillimum…with The Other Song 

by Dr. Divya Chhabra on 4 th and 5 th August 2012 at 

Mumbai, India. Download full brochure here. 

How to live your life homeopathically and why: 

13.07.2012 Whole Foods Market, Plymouth Meeting, 

500 West Germantown Pike, Plymouth Meeting, 

PA, Free Friday evening talk, Time: 7 to 8:30 pm. 

For more info call / email: 541.552.1400 or 

drfalkner@qwest.net 

Homeopathy Through Simplicity, 14 – 15.07.2012 

Whole Foods Market, Plymouth Meeting, 500 West 

Germantown Pike, Plymouth Meeting, PA 

Speaker: Douglas Falkner, MD, MHom 

Presented by: The Polaris Institute of Homeopathy 

Time: 9:30-5pm 

Cost: $295 for both days- discount if you register 

early. To register call Douglas Falkner at: 

541.552.1400 or email: drfalkner@qwest.net 

5th Congress for Integrative Medicine ECIM 2012 

Full brochure at www.audesapere.in/events 

Registration: www.ecim-congress.org Info: 

ecim2012@regione.toscana.it 

The 5th European Congress for Integrative 

Medicine will take place in Florence (Italy) on 

September 21-22, 2012. The opening ceremony will 

be held at Salone dei Cinquecento - Palazzo Vecchio 

on September 20. The Congress is promoted by the 

Tuscan Region, University of Florence, Chamber of 

Medical Doctors and Dentists of Florence with the 

Charité University of Berlin, in co-operation with 

the other Tuscan Universities, with the patronage 

of European and international societies and 

institutions. This is the main European and 

international event for physicians, healthcare and 

wellness professionals, researchers, and sponsors 

about the efficacy of 

complementary/unconventional medicines and 

practices and their integration with orthodox 

medicine. The aim of ECIM 2012 is to link 

researchers and medical doctors in order to 

promote a constructive dialogue and discussion 

about the clinical efficacy and the methodology of 

medical care, research and education. Not only to 

disseminate the experiences of integration of 

complementary medicine into the National Health 

Services but also to aim at the real integration with 

the medicine also by drawing up appropriate 

guidelines. ECIM 2012 will host workshops of 

national and international societies and 

institutions. ECIM 2012 will also host the XXVI 

G.I.R.I. Congress (International Research Group on 

Very Low Dose and High Dilution Effects), about 

the biologic effects of very low dose and ultradiluted 

substances. The abstracts of the Congress 

will be published in the European Journal of 

Integrative Medicine. 

Clinical Classes for NESH Alum, 20 – 22.07.2012 

New England School of Homeopathy – Seattle, WA 

This Clinical Course is offered only to those 

individuals who have completed a full NESH 

program either in Amherst, Seattle, Portland, 

Florida or abroad. 

Instructors: Drs. Paul Herscu ND and Amy 

Rothenberg ND mail to: nesh@nesh.com, 413-256- 

5949, fax 860-253-5041

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