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22 1.3 REACTION SCHEMES 1.3.1 Scheme 1 H 3 C O H 3 C HNO 2 H 3 C O H 3 C O O O O Zn/CH 3 COOH N OH C H 3 O O H 3 C O NH 2 acetyl acetone O H 3 C CH 3 CH 3 O O N H H 3 C 1.3.2 Scheme 2 R O H H 3 C CH 3 3 C O + O N H CH 3 O H R KOH CH 3 OH O H 3 C O H 3 C CH 3 O N H
23 1.3.3 Scheme 3 O H H 3 C 3 C O NH 2 NH 2 O N H CH 3 C 2 H 5 OH, reflux R C H 3 O H 3 C CH 3 O N H N H N R 1.3.4 REACTION MECHANISM H 3 RC O + R 1 +H + C O R 1 +H + H 3 R .. NH 2 O CH 3 -H + + NH 2 CH 3 -H + OH H 3 C O H 3 C O R .. NH OH R 1 +H + CH 3 -H + R .. NH R 1 -H 2 O +H 2 O CH 3 OH 2 + H 3 C O R 1 H 3 C O R 1 -H + +H + R NH + CH 3 +H + R .. NH CH 3 -H + H 3 HR OC H R + N R 1 H CH 3 R 1 H 3 -H + HOC -H + +H + H +H N CH + 3 R H H 3 C R 1 H 2 O + H .. N CH 3 R H -H 2 O +H 2 O H 3 C R 1 H N + CH 3 R H C -H + N R 1 R= COOC 2 H 5 R= COCH 3 1 3 CH RH 3 H
Page 1 and 2: Saurashtra University Re - Accredit
Page 3 and 4: Statement under O.Ph.D.7 of Saurash
Page 5 and 6: To My Family, With Love
Page 7 and 8: I would like to thank my dear lab m
Page 9 and 10: Synthetic Aspects 55 QSAR Study 59
Page 11 and 12: CHAPTER-6 MICROWAVE ASSISTED SYNTHE
Page 13: Chapter-1 Introduction, Synthesis a
Page 16 and 17: 2 Their biological functions are as
Page 18 and 19: 4 5. The reaction of β-amino-α,
Page 20 and 21: 6 5. A general, highly flexible Cu-
Page 22 and 23: 8 11. A new microwave-assisted rear
Page 24 and 25: 10 Gaetano Dattolo 38 and his resea
Page 26 and 27: 12 -CONHOCH 3 O -CONHNH 2 Cl C N F
Page 28 and 29: 14 Molecular modeling and docking c
Page 30 and 31: 16 R 3 R 4 R 1 ,R 2 ,R 3 ,=H, alkyl
Page 32 and 33: 18 CH 3 CH 3 N C O NH H 3 CH 3 F N
Page 34 and 35: 20 Drug Name Chemical Structure : :
Page 38 and 39: 24 1.4 Experimental Protocols Comme
Page 41 and 42: 27 1.7 SPECTRAL ANALYSIS 1.7.1 IR S
Page 43 and 44: 29 of phenyl ring from molecule, ba
Page 45 and 46: 31 Ethyl 3,5-dimethyl-4-[5-(3-nitro
Page 47 and 48: 33 C, H, N (in %): Found: 60.62(C),
Page 49 and 50: 35 IR (KBr) cm -1 : 3320, 3246 (-NH
Page 51 and 52: IR spectrum of Ethyl 4-[5-(4-methox
Page 53 and 54: 39 1 H NMR spectrum of Ethyl 3, 5-d
Page 55 and 56: 41 1 H NMR spectrum of Ethyl 3, 5-d
Page 57 and 58: Mass spectrum of Ethyl 3, 5-dimethy
Page 59 and 60: 45 Mass spectrum of Ethyl 3, 5-dime
Page 61 and 62: 47 29. Ekkati A. R., Bates D. K., S
Page 63 and 64: Chapter-2 Introduction, Synthesis a
Page 65 and 66: 50 with improved bioavailability, t
Page 67 and 68: 52 combining Ca 2+ antagonism and t
Page 69 and 70: 54 alpha1G, expressed in Xenopus oo
Page 71 and 72: 56 3,5-Dibenzoyl-4-(3-phenoxyphenyl
Page 73 and 74: 58 PAF, will have clinical utilitie
Page 75 and 76: 60 According to the 3D QSAR study,
Page 77 and 78: 62 2.3.3 Scheme 3 O O R HN CH 3 O H
Page 79 and 80: 64 2.5 EXPERIMENTAL 2.5.1 N-(naphth
Page 81 and 82: 66 2.6 PHYSICAL DATA TABLE 2.6.1 Ph
Page 83 and 84: 68 2.7 SPECTRAL DISCUSSION 2.7.1 IR
Page 85 and 86: 70 ionization chamber and resolved
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72 C, H, N (in %): Found: 78.10 (C)
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74 1,4- Dihydro -4- (4-hydroxy phen
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76 C, H, N (in %): Found: 69.87 (C)
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IR spectrum of 1,4- dihydro-4-(4-me
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1 H NMR spectrum of 1,4- dihydro-4-
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1 H NMR spectrum of 1,4- dihydro-4-
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84 REFERENCES 1. Alker, D.; Arrowsm
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86 51. Pickard, J. D.; Murray, G. D
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Chapter - 3 A mini review of Dihydr
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urea, is the first intermediate in
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91 A variety of substituted aromati
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93 first organocatalytic asymmetric
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95 one system in high yield and hig
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97 classical dihydropyridine calciu
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99 Atwal et al 58 examined a series
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101 biological activity. Biological
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103 Applying intramolecular Heck re
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105 furo[3,4-d]pyrimidines, pyrrolo
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107 Figure 2: The reaction of 2-ami
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109 O O O R 1 NH ClCH 2 COOH R 1 N
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111 A N B N O S R 1 3.6 Biginelli R
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113 3.7.1 Name reactions Following
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115 and urea or thiourea to afford
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117 3.8.1 Cycloaddition reaction Re
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119 3.8.5 Solid Phase Organic Synth
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121 Lusch and Tallarico 31 reported
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123 continuation of this work, it w
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124 INTRODUCTION A general introduc
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126 4.1.2 Scheme-2 R 2 O R 1 NH NH
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128 4.1.5 Reaction Mechanism O NH N
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130 4.3.2 N - (Substituted phenyl)-
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132 13. AKS- 562 4-F 2,3,5,6- 441.5
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134 14 AKS-583 4-F 3-OCH 3 397.46 1
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136 4.5 SPECTRAL ANALYSIS Spectral
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gave multiplet signal at similar re
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140 IR(KBr)cm -1 :3192 (-NH,str),31
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142 N - (4-Fluoro phenyl) -5- (3-me
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144 Mass: 435 (2), 431 (10), 416 (3
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IR spectrum of N,6-Bis(4-chlorophen
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1 H NMR Spectrum of 5-(2-Chlorophen
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150 1 H NMR Spectrum of N-(4-Chloro
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152 1 H NMR Spectrum of N,6-Bis(1-n
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Mass Spectrum of N-(4-Chlorophenyl)
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Mass Spectrum of 5-(2-Chlorophenyl)
Page 175 and 176:
Chapter-5 Synthesis and Characteriz
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159 5.1 REACTOIN SCHEMES 5.1.1 Sche
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161 5.2 Experimental 5.2.1 N-Substi
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163 5.3 PHYSICAL DATA 5.3.1 Physica
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165 AKS-916 2,4diCH 3 4-Cl 3,4,5-tr
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167 The supplementary characterizat
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169 IR(KBr,cm -1 ): 3292-3228 (-NH)
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171 IR(KBr,cm -1 ): 3312-3215 (-NH)
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173 N-(2,4-Di-methylphenyl)-N-(4-ch
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IR spectrum of 4-(phenyl)-N-(4-chlo
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IR spectrum of 4-(4-flourophenyl)-N
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1 H NMR spectrum of 4-(4-hydroxyphe
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1 H NMR spectrum of N-(3-methylphen
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Mass spectrum of 4-(2,3-benzophenyl
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184 INTRODUCTION The current chapte
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186 6.1.3 Scheme-3 CH 3 R NH O H 3
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188 6.2 EXPERIMENTAL N- (Substitute
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190 6.3.2 Physical data of 6-methyl
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192 at 7.59 δ ppm with J value 8.8
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194 N-(4-Flourophenyl)-6-methyl-2-o
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196 C, H, N (in %): Found: 71.72 (C
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198 C, H, N (in %): Found: 68.09 (C
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IR spectrum of N-( 4-Flouro phenyl)
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1 H NMR spectrum of N-(4-Fluorophen
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Mass spectrum of N-(2,3-Dimethylphe
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206 References 1. Kappe, C. O.; Acc
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208 54. Forray, C.; Bard, J. A.; We
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210 96. Manhi, M. and Abdel-Fattah,
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212 153. Trost, B. M.; Crawley, M.
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213 Biological Activity Study The p
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215 Incubation time and temperature
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217 34. AKS-904 -- - - - 100 100 35
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234 SUMMARY OF WORK The work presen
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236 Presentation of Paper & Confere
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