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21
Chemical Structure :
CH 3
N
N
O
H 3 C
O
S
O
H 3 C
O
Chemical Name
Phase
Activity
: 2-[4,5-Bis(4-methoxyphenyl)thiazol-2-yl]
Pyrrole-1-aceticacid ethyl ester
: pre-registered
: Antiplatelet Therapy; Cyclooxygenase
Inhibitors
1.2 SYNTHETIC ASPECT
In the present chapter, the aspect was to develop the molecules of
pharmacological interest, encircled different heterocyclic ring system with pyrrole
ring which is documented as significant pharmacophore for treatment of
tuberculosis, HIV, schizophrenia, anxiety, depression, circadiac rhythm disorders,
diabetes, impaired glucose tolerance tumors, autoimmune disease and many
others.
Serving as an excellent intermediate with other chemical structures leading to
large number of heterocycles, pyrrole it self is very well explored in analytical and
pharmaceutical chemistry and their biological properties are also documented in
last few years. This data promoted us to investigate the biological properties of
this structure class.
Earlier in our laboratory, pyrrole derivatives with oxadiazole ring on side chain are
synthesized and their biological profile showed promising results. In continuation
of this work pyrrole derivatives with pyrazol ring on side chain are synthesized in
current chapter. The physical data and spectral data of synthesized compounds
are given in Section 1.6 and 1.7.