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in the presence of AlCl 3 in dichloro ethane for 16 hrs. This compounds exhibited
anticonvulsant activity on the mouse.
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R 3
Z
B
Cl
O
N
A
O
R 2
N
R 1
O
CH 3
Z
A
R 3
N
R 1
B
O
R 2
A =(un)substituted aryl, heteroaryl
B =(un)substituted heteroaryl
Z =oxo, hydroxy
R 1
= (un)substituted alkyl, cycloalkyl,aryl
R 2
,R 3
=independently H, alkyl, halogen
Kaizeman 46 et al has discovered potent DNA groove binding antibacterials which
has shown improved tolerability in vivo and in vitro with excellent antibacterial
potency against broad Gram positive pathogens, including drug resistant strains
such as methicillin-resistant Staphylococcus aureus, penicillin-resistant
Streprococcus pneumonia and vancomycin-resistant Enterococcus faecalis.
R
O
NH
N
NH
N
H 3
CH 3 O
C
O
N
NH
N
NH
O
O
CH 3
Pyrrole derivatives and their salts having structure type, shown below are useful
as inhibitors of the human immunodeficiency virus (reverse transcriptase)
enzyme which is involved in viral replication and consequently may be
advantageously used as therapeutics agents for HIV mediated process. 47