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R 2
R 1
R 3
O
R 4
R 5 NH 2
0.5 eq. MgSO 4
MeCN, 80 °C
16 - 63 h
R 1
R 2
R 3
N
R 5
R 4
14. Several aryl-substituted pyrrole derivatives were prepared conveniently in a
microwave-assisted one pot-reaction from but-2-ene-1,4-diones and but-2-yne-1,
4-diones via Pd/C-catalyzed hydrogenation of the carbon-carbon double
bond/triple bond followed by amination-cyclization 36 .
O
Ar
O
Ar
+ R NH 2
MW, 200 W
PEG - 200
5 % Pd/C
0.5 -1 min
Ar
O
HO
Ar
NHR
Ar
N
R
A
1.1.3 Biological profile
Ghassan abdalla 37 and his coworkers has discovered [3,2-b]-pyridine-6-
carboxylic acid from 2-methyl-3-benzoyl-4-amino pyrrole as potential
antimicrobial agents.
CH 3
CH 3
O
N
C H 3
O
H
O
OH