Alligator Bioscience AB - Redeye
Alligator Bioscience AB - Redeye
Alligator Bioscience AB - Redeye
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Immunotherapy of Cancer<br />
Objective: To develop immunotherapies to boost the immune system<br />
to eradicate tumors and metastases with minimal systemic toxicity.<br />
Clinical Validation of Immunotherapy<br />
Ø Yervoy® (BMS) approved by FDA for metastatic melanoma<br />
Ø Clinical effect at the cost of severe immune-mediated adverse effects<br />
Drawback of Immunotherapy Addressed by Intratumoral Administration*<br />
Ø Concept of local immunotherapy pioneered by Prof. Tötterman<br />
Ø <strong>Alligator</strong> has collaborated with Prof. Tötterman since 2008 in order to develop<br />
the first therapeutic antibodies for local immunotherapy of cancer<br />
6<br />
*) Malmström et al., Clinical Cancer Research 2010:16 : 3279-87<br />
Pesonen et al., Cancer Research 2012: 72: 1621-31<br />
Castro et al., Cancer Research 2012: 72: 2937-48<br />
CONFIDENTIAL
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