Survival of Listeria in processed meat and poultry products

dose-response (pregnant animals)
• Smith et al. (2003, 2008) - pregnant monkeys, virulent strains
– LD 50 lower = 3.63 x 10 6 , LD 50 upper = 4.27 x 10 8
• Williams et al. (2007) - pregnant guinea pigs
– LD 50 lower = 3.52 x 10 6 , LD 50 upper = 1.13 x 10 8
– (n.b guinea pigs have been identified as the small animal of choice for L. monocytogenes studies
because of the E-cadherin molecule which interacts with the internalin protein of L.
monocytogenes)
Listeria Summit, Sydney, 2010