Research Profile - Department of Materials Science and Metallurgy ...
Research Profile - Department of Materials Science and Metallurgy ...
Research Profile - Department of Materials Science and Metallurgy ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Serena Best<br />
Reader in Ceramics <strong>and</strong> Medical <strong>Materials</strong><br />
BSc University <strong>of</strong> Surrey<br />
PhD University <strong>of</strong> London<br />
+44 (0) 1223 334307<br />
smb51@cam.ac.uk<br />
www.msm.cam.ac.uk/ccmm/<br />
Bioactive Ceramics, Coatings <strong>and</strong> Composites<br />
My research within the Cambridge Centre for Medical <strong>Materials</strong><br />
aims to exp<strong>and</strong> the range <strong>and</strong> performance <strong>of</strong> bioactive ceramics<br />
<strong>and</strong> composites in clinical applications.<br />
Skeletal implants: Optimization <strong>of</strong> substituted<br />
hydroxyapatite bone grafts<br />
A range <strong>of</strong> synthetic substituted hydroxyapatite (HA) materials<br />
has been developed with physiologically relevant ionic lattice<br />
substitutions. The materials are designed for skeletal defect filling<br />
<strong>and</strong> as scaffolds for tissue engineering. The performance <strong>of</strong> these<br />
materials is evaluated alongside phase-pure HA <strong>and</strong> bioactive<br />
glasses <strong>and</strong> glass ceramics through in-vitro cell culture <strong>and</strong> invivo<br />
implantation models.<br />
Surface modification using bioceramics<br />
The repair <strong>of</strong> bone defects can be enhanced by the control <strong>of</strong><br />
either the surface chemistry or topography. This research area<br />
encompasses a number <strong>of</strong> projects to deposit bioactive ceramics<br />
on a range <strong>of</strong> substrates. Deposition techniques include RFsputtering,<br />
electrostatic atomization <strong>and</strong> vacuum plasma<br />
spraying to produce a range <strong>of</strong> surface topographies.<br />
Bioactive <strong>and</strong> bioresorbable composites for tissue<br />
engineering<br />
We aim to develop composites with properties tailored to<br />
their specific application. The organic matrices range from<br />
collagen to biodegradable polymers. The fillers include bioactive<br />
ceramics, glasses <strong>and</strong> glass ceramics. Filler particles with a<br />
variety <strong>of</strong> morphologies <strong>and</strong> dimensions are being investigated.<br />
The biological response to carbon nanotubes is also being<br />
explored with the aim <strong>of</strong> producing ceramic-matrix composites<br />
with optimized mechanical properties.<br />
N Patel, RA Brooks, MT Clarke, PMT Lee, N Rushton, I Gibson, SM Best &<br />
W Bonfield, “In vivo assessment <strong>of</strong> hydroxyapatite <strong>and</strong> silicate substituted<br />
hydroxyapatite granules using an ovine defect model” J. Mater. Sci: Mater.<br />
Med. 16, 429–440 (2005).<br />
ES Thian, J Huang, ME Vickers, SM Best, ZH Barber & W Bonfield,<br />
“Silicon-substituted hydroxyapatite (SiHA): A novel calcium phosphate<br />
coating for biomedical applications” J. Mater. Sci. 41, 709–717 (2006).<br />
AE Porter, T Buckl<strong>and</strong>, K Hing, SM Best & W Bonfield, “The structure <strong>of</strong><br />
the bond between silicon-substituted hydroxyapatite bone <strong>and</strong> porous<br />
bioceramic implants” J. Biomed. Mater. Res. A 78A, 25–33 (2006).<br />
Confocal image <strong>of</strong> osteoblast cells attaching on siliconsubstituted<br />
hydroxyapatite nanocrystals<br />
6 <strong>Research</strong> <strong>Pr<strong>of</strong>ile</strong>