CV and abstract Marco Capogna - B·Debate
CV and abstract Marco Capogna - B·Debate
CV and abstract Marco Capogna - B·Debate
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<strong>CV</strong><br />
SPEAKER AT:<br />
<strong>Marco</strong> <strong>Capogna</strong>, MRC Anatomical Neuropharmacology Unit, Oxford, UK<br />
<strong>Marco</strong> <strong>Capogna</strong>, PhD in Neuroscience, is a Senior Scientist <strong>and</strong> Group Leader at the<br />
Medical Research Council, Anatomical Neuropharmacology Unit, Oxford, UK since<br />
2001. He previously held a position as Head of the Neurophysiology Lab. at Novartis<br />
Institute for Medical Sciences, University College, London, UK. He was postdoctoral<br />
fellow at the Brain Research Institute of the University of Zurich, Switzerl<strong>and</strong>. His<br />
research is currently supported by the Medical Research Council <strong>and</strong> by the Wellcome<br />
Trust, UK. Dr. <strong>Capogna</strong>’s research aims to underst<strong>and</strong> what neuronal circuitry guides<br />
emotional-dependent behaviours, <strong>and</strong> how it is modified in animal models of fear <strong>and</strong><br />
anxiety disorders. To achieve this goal he studies the functional role of identified<br />
neuronal types of the rodent hippocampus <strong>and</strong> amygdala with emphasis on GABAergic<br />
neurons. Key research activities are: (i) synaptic transmission between identified<br />
neurons of hippocampus <strong>and</strong> amygdala, (ii) contribution of identified neurons to<br />
neuronal networks, (iii) pharmacology of GABAergic synapses.
<strong>CV</strong><br />
SPEAKER AT:<br />
Theta network oscillations: focus on GABAergic interneurons of amygdala<br />
<strong>and</strong> hippocampus.<br />
<strong>Marco</strong> <strong>Capogna</strong>, MRC Anatomical Neuropharmacology Unit, Oxford, UK<br />
Dr. <strong>Capogna</strong>'s talk will focus on the contribution of specific GABAergic cell types of the<br />
amygdala <strong>and</strong> hippocampus to the so-called theta network oscillation. This brain<br />
rhythm occurs during REM sleep, arousal, locomotion, mnemonic process, <strong>and</strong> can be<br />
partially disrupted during neurological <strong>and</strong> psychiatric diseases. In the first part of the<br />
talk, the speaker will show that different types of GABAergic cells are active at<br />
different phases of neuronal theta oscillations thereby controlling the activity of<br />
postsynaptic cells at different times. In the second part of the talk, Dr. <strong>Capogna</strong> will<br />
demonstrate that GABA-A receptor-mediated events elicited by various interneuron<br />
types display distinct duration <strong>and</strong> synaptic plasticity, <strong>and</strong> that these factors are crucial<br />
in determining their physiological influence on target neurons. Therefore, the<br />
mechanisms underlying the time course <strong>and</strong> the dynamic properties of inhibitory<br />
synaptic responses will be discussed. In the last part of the talk Dr. <strong>Capogna</strong> will<br />
present the hypothesis that the oscillatory rhythms of the brain are altered during<br />
disease, <strong>and</strong> discuss his plans to test this idea.