New Drug Update 2009-2010 - LAFP
New Drug Update 2009-2010 - LAFP
New Drug Update 2009-2010 - LAFP
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Other warnings and precautions are typical for the class and include suicide risk, neuroleptic malignant<br />
syndrome, tardive dyskinesia, disruption of body temperature regulation, dysphagia, and the potential for<br />
cognitive and motor impairment.<br />
The safety and effectiveness of iloperidone have not been established in children.<br />
Iloperidone is in Pregnancy Category C. In animal models, iloperidone caused developmental toxicity but<br />
was not teratogenic. It should be used in pregnancy only if the potential benefit justifies the potential risk<br />
to the fetus.<br />
Iloperidone was excreted in milk of rats during lactation. It is not known whether iloperidone or its<br />
metabolites are excreted in human milk. It is recommended that women receiving iloperidone not breastfeed.<br />
Table 4. Contraindications, Warnings, and Precautions of the Benzisoxazole Antipsychotics<br />
Contraindications<br />
Iloperidone Paliperidone Risperidone Ziprasidone<br />
Hypersensitivity X X X X<br />
QT prolongation<br />
Black Box Warnings<br />
Increased mortality<br />
in elderly patients<br />
with dementiarelated<br />
psychoses<br />
Warnings and Precautions<br />
Cerebrovascular<br />
events in elderly<br />
patients with<br />
dementia- related<br />
psychoses<br />
X X X X<br />
X X X X<br />
QT prolongation X X X<br />
Neuroleptic<br />
malignant<br />
syndrome<br />
X X X X<br />
Tardive dyskinesia X X X X<br />
Hyperglycemia/<br />
diabetes mellitus<br />
Weight gain<br />
X X X X<br />
X<br />
Seizures X X X X<br />
Orthostatic<br />
hypotension<br />
X X X X<br />
Hyperprolactinemia X X X X<br />
Body temperature<br />
regulation<br />
X X X X<br />
Dysphagia X X X X<br />
Suicide X X X X<br />
X<br />
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