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Anaphylaxis in Schools 3rd Edition

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Consensus Statement<br />

Understand<strong>in</strong>g <strong>Anaphylaxis</strong><br />

What is anaphylaxis?<br />

<strong>Anaphylaxis</strong> (pronounced anna-fill-axis) is a serious allergic reaction that is rapid <strong>in</strong> onset and may<br />

cause death. 1 An allergen is a substance capable of caus<strong>in</strong>g an allergic reaction. Upon first exposure<br />

<strong>in</strong> <strong>in</strong>dividuals who are predisposed to allergy, the immune system treats the allergen as someth<strong>in</strong>g to<br />

be rejected rather than tolerated. This process is called sensitization. Re-exposure to the same allergen<br />

<strong>in</strong> the now-sensitized <strong>in</strong>dividual may result <strong>in</strong> an allergic reaction which, <strong>in</strong> its most severe form, is<br />

called anaphylaxis.<br />

How common is it?<br />

While the exact prevalence is unknown, it has been estimated that up to 2% of Canadians are at risk<br />

of anaphylaxis from food and <strong>in</strong>sect allergy. 2 This currently represents about 700,000 Canadians.<br />

What are the signs and symptoms?<br />

Signs and symptoms of a severe allergic reaction can occur with<strong>in</strong> m<strong>in</strong>utes of exposure to an allergen.<br />

In rarer cases, the time frame can vary up to several hours after exposure. The ways these symptoms<br />

occur can vary from person to person and even from episode to episode <strong>in</strong> the same person.<br />

Symptoms of anaphylaxis generally <strong>in</strong>clude two or more of the follow<strong>in</strong>g body systems: sk<strong>in</strong>, respiratory,<br />

gastro<strong>in</strong>test<strong>in</strong>al and/or cardiovascular. However, low blood pressure alone (i.e. cardiovascular system),<br />

<strong>in</strong> the absence of other symptoms, can also represent anaphylaxis. 1,3<br />

• Sk<strong>in</strong>: hives, swell<strong>in</strong>g (face, lips, tongue), itch<strong>in</strong>g, warmth, redness<br />

• Respiratory (breath<strong>in</strong>g): cough<strong>in</strong>g, wheez<strong>in</strong>g, shortness of breath, chest pa<strong>in</strong> or tightness, throat<br />

tightness, hoarse voice, nasal congestion or hay fever-like symptoms (runny, itchy nose and watery<br />

eyes, sneez<strong>in</strong>g), trouble swallow<strong>in</strong>g<br />

• Gastro<strong>in</strong>test<strong>in</strong>al (stomach): nausea, pa<strong>in</strong> or cramps, vomit<strong>in</strong>g, diarrhea<br />

• Cardiovascular (heart): paler than normal sk<strong>in</strong> colour/blue colour, weak pulse, pass<strong>in</strong>g out,<br />

dizz<strong>in</strong>ess or lightheadedness, shock<br />

• Other: anxiety, sense of doom (the feel<strong>in</strong>g that someth<strong>in</strong>g bad is about to happen), headache,<br />

uter<strong>in</strong>e cramps, metallic taste<br />

Because of the unpredictability of reactions, early symptoms should never be ignored, especially if the<br />

person has suffered an anaphylactic reaction <strong>in</strong> the past. It is important to note that anaphylaxis can<br />

occur without hives.<br />

6<br />

<strong>Anaphylaxis</strong> <strong>in</strong> <strong>Schools</strong> & Other Sett<strong>in</strong>gs<br />

Copyright © 2005-2014 Canadian Society of Allergy and Cl<strong>in</strong>ical Immunology

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