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Content
Chapter 1
Palladium Catalyzed Synthesis of Novel Highly Functionalized
Pyrimidines via Suzuki-Miyaura Coupling Reaction.
1.1 Introduction 1
1.2 Biological Activity Associated with 4-Aryl dihydropyrimidine derivatives 2
1.3 Synthetic strategies for the dihydropyrimidines (DHPMs) 7
1.4 Current research work 20
1.5 Results and discussion 21
1.6 Conclusion 24
1.7 Experimental section 25
1.8 References 40
Chapter 2
Synthesis and Biological Activity of Novel Pyrimidine Derivatives via
Wittig Reaction in Aqueous Media.
2.1 Introduction 44
2.2 A literature review on the biological activity associated with pyrimidine
derivatives 45
2.3 Various synthetic approaches for highly substituted pyrimidines 50
2.4 Applications of Wittig reaction 52
2.5 Application of sodium tripolyphosphate 55
2.6 Current research work 56
2.7 Results and discussion 57
2.8 Antimicrobial sensitivity testing 60
2.9 Conclusion 63
2.10 Experimental section 64
2.11 References 79
Chapter 3
Rapid Synthesis and Characterization of Novel Tri-substituted
Pyrazoles/Isoxazoles Library Using Ketene Dithioacetals.
3.1 Introduction 82
3.2 Biological activity associated with pyrazoles and isoxazoles 83
3.3 Synthetic methods for the pyrazole and isooxazole derivatives 89
3.4 Some pharmaceutical molecules related to pyrazoles and isoxazoles 94
3.5 Current research work 95
3.6 Results and discussion 96
3.7 Conclusion 100
3.8 Experimental section 101
3.9 References 118