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Chapter 2
Synthesis of substituted pyrimidines via Wittig
2.9 Conclusion
We have described a versatile synthesis of novel 2-chloro-4-(4-fluorophenyl)-
6-isopropyl-5-(E)-substituted pyrimidines from triphenyl[2-chloro-{4-(4-flouro
phenyl)-6-isopropyl-pyrimidin-5-ylmethyl}phosphonium]bromide with different
aldehydes via Wittig reaction in the presence of sodium tripolyphosphate as a base in
aqueous media. Inorganic base sodium tripolyphosphate has the further advantage of
low cost, stability and low toxicity. All the synthesized compounds were evaluated
for their antimicrobial activity. The investigation of antibacterial and antifungal
screening data revealed that all the tested compounds AW-01 to AW-20 showed
moderate to significant activity. For example, compounds AW-02, 12, 13 and 18
showed comparatively good activities against all the bacterial strains and thus
warrant further study.
Department of Chemistry, Saurashtra university, Rajkot-360005 63