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Chapter 2<br />
Synthesis of substituted pyrimidines via Wittig<br />
2.6 Current research work<br />
As described in earlier, the chemistry of pyrimidines is one of the most widely<br />
studied subjects because of the occurrence of such heterocycles in biologically<br />
relevant systems such as nucleic acids, cofactors, various toxins, and other products.<br />
Pyrimidine derivatives are biologically interesting molecules that have established<br />
utility for the treatment of Alzheimer’s disease and proliferative disorders; they are<br />
also capable of showing antiviral activity, anti-HIV agents, anti hypertensive agents,<br />
antimicrobial agents and fungicide. The witting product of pyrimidine derivatives<br />
such as rosuvastatin and its salt, which are HMG-CoA reductase inhibitor and useful<br />
in treatment of hypercholesteromia, hyperlipoproteinemia and atherosclerosis.<br />
The Wittig olefination reaction is regarded as one of the most strategic, widely<br />
applicable carbon–carbon double bond-forming processes available in organic<br />
synthesis. This reliable reaction allows for olefination with complete positional<br />
selectivity, predictable chemoselectivity and may be conducted in many cases with<br />
reliable and high stereocontrol.<br />
Nowadays, a great deal of effort has been focused on the field of green<br />
chemistry in adopting methods and processes. As a part of this “green” concept, toxic<br />
and/or flammable organic solvents are replaced by alternative non-toxic and<br />
nonflammable media. In this context, many efforts have been made to use aqueous<br />
media. Among alternative green solvents, water has been the solvent of choice for a<br />
variety of transformations.<br />
During the course of our ongoing interest on the synthesis various<br />
heterocycles and development of useful synthetic methodology, we have developed a<br />
small library of pyrimidines via Wittig reaction using sodium tripolyphosphate as<br />
base in aqueous media. The newly synthesized compounds were characterized by IR,<br />
Mass, 1 H NMR, 13 C NMR spectroscopy and elemental analysis. All the newly<br />
synthesized compounds were evaluated for their antimicrobial activity.<br />
Department of Chemistry, <strong>Saurashtra</strong> university, Rajkot-360005 56