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Chapter 2
Synthesis of substituted pyrimidines via Wittig
2.5 Application of sodium tripolyphosphate
Sodium tripolyphosphate (STPP) is white powder an inorganic compound
with formula Na 5 P 3 O 10 . It is the sodium salt of the polyphosphate penta-anion, which
is the conjugate base of triphosphoric acid (Figure-31). STPP is widely used in
detergents, and as a preservative for seafood, meats, poultry, and animal feeds. It is
also use in ceramics, anticaking, setting retarders, flame retardants, paper,
anticorrosion pigments, textiles, rubber manufacture, fermentation, antifreeze.
Figure-31
There is some limited application of STTP in organic synthesis; however
Zhiqiang Zhang et al. 52 have described a conversion of methyl lactate to acrylic acid,
methyl acrylate and lactic acid via various reactions such as dehydration,
decomposition, decarbonylation, hydrolysis and esterification has been determined by
using sodium tripolyphosphate as a catalyst.
Tert-butyl-2-bromoacetate was synthesized by a reaction of 2-bromoacetyl
chloride with tert-butanol at room temp used stoichiometric sodium tripolyphosphate
as catalyst and acid-scavenger, chloroform as solvent to afford 93% yield. 53 α-
Bromoisobutyric acid tert-butyl ester was synthesized by reaction of tert-Bu alc. with
α-bromoisobutyryl bromide using stoichiometric sodium tripolyphosphate as a base to
afford 96.5% yield. 54
Department of Chemistry, Saurashtra university, Rajkot-360005 55