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Chapter 1
Synthesis of functionalized pyrimidines
1.6 Conclusion
In conclusion, we have developed an efficient four step protocols for the
synthesis of diversely substituted novel pyrimidines. A series of chlorinated
pyrimidines were synthesized from easily available biginelli 3,4-dihydropyrimidin-
2(1H)-ones. The chlorinated pyrimidines were then subjected to condition normally
employed Suzuki-Miyaura coupling reaction with various phenylboronicacid
derivatives in the presence of palladium catalyst to obtain C-phenyl pyrimidines with
good yields. A variety of commercially available 1,3-diketones and various
substituted aldehydes and boronic acids can be used as building blocks to generate
diversity on the core pyrimidine ring systems.
Department of Chemistry, Saurashtra University, Rajkot-360005 24