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Chapter 1 Synthesis of functionalized pyrimidines David X. Yang et al. 77 has reported palladium-catalyzed Suzuki-Miyaura coupling of Pyridyl-2-boronic esters with aryl halides using highly active and airstable phosphine chloride and oxide Ligands (Figure-47). FG N O B O ArX or HetArX Dichloropalladiuym oxide/chloride Base, solvent FG N or Ar FG N HetAr Figure-47 Department of Chemistry, Saurashtra University, Rajkot-360005 19
Chapter 1 Synthesis of functionalized pyrimidines 1.4. Current research work The literature survey described above has demonstrated that the pyrimidine derivatives possesses a variety of biological activity, among which are the analgesic, antihypertensive, antipyretic, antiviral and anti-inflammatory activity. These agents are also associated with nucleic acid, antibiotic, antimalarial and anti cancer drugs. Many of the pyrimidine derivatives are reported to possess potential CNS depressant properties. However, to our knowledge functionalized pyrimidines such as 4- isopropyl-2,6-di-phenylsubstituted derivatives are less studied (Figure-48). The tremendous biological potential of pyrimidine derivatives encouraged us to prepare some novel highly functionalized pyrimidines bearing 4-isopropyl-2-6-disubstitutedphenylpyrimidine-5-carboxylate functions. R O N O R 1 N ASM-4a-t Figure-48 Herein we described a series of novel and efficient protocol for the synthesis of diversely substituted pyrimidines. A series of chlorinated pyrimidines were synthesized from easily available Biginelli 3,4-dihydropyrimidin-2(1H)-ones. The chlorinated pyrimidines were subjected to the Suzuki-Miyaura coupling reactions with various phenylboronicacid derivatives to obtain C-phenyl pyrimidines. The newly synthesized compounds are characterized by IR, Mass, 1 H NMR, 13 C NMR spectroscopy and elemental analysis. . Department of Chemistry, Saurashtra University, Rajkot-360005 20
Page 1 and 2: Saurashtra University Re - Accredit
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Chapter 2 Synthesis of substituted
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Chapter 3 Synthesis of trisubstitut
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Chapter 4 Synthesis of highly subst
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Chapter-5 Synthesis of highly subst
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Chapter 6 Synthesis of benzodiazepi
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pyrazole derivative were faster and
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Conferences participated 1. “15 t
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