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pyrazole derivative were faster and afforded the pyrazolo[1,5-a]pyrimidine in good
yield in the presence of K 2 CO 3 as a base and isopropyl alcohol. This study led to the
development of a simple approach for synthesis of pyrazolo[1,5-a]pyrimidines,
substances that potentially interesting biological and medicinal properties.
Chapter 5 described the synthesis of a series of substituted pyrroles as a
atorvastatin analogs. The targeted compound were achieved from novel 1,4-
dicarbonyl compounds and amino side chain using pivalic acid as a catalyst and
cyclohexane and THF as binary solvent under microwave irradiation technique. All
the synthesized compounds were evaluated for their antimicrobial activity. The
investigation of antibacterial and antifungal screening revealed that some of these
agents posseses moderate to potent activity.
In Chapter 6, we have demonstrated a simple and effective strategy for the
synthesis of novel 1-and 3-substituted 1,4-benzodiazepines. The reaction of 1,4-
benzodiazepines either with various alkyl halide or a variety of aromatic aldehydes in
the presence of potassium hydroxide afforded the desired 1-and 3-substituted 1,4-
benzodiazepine derivatives in excellent yields.
Department of Chemistry, Saurashtra university, Rajkot-360005 235