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Chapter 1
Synthesis of functionalized pyrimidines
Rui Liang et al. 56 has shown the oxidation of 3,4-Dihydropyrimidin-2(1H)-
ones (DHPMs) with 1.2 eq. of nitrosonium tetrafluoroborate (NO + BF - 4 ) to pyrimidin-
2(1H)-ones in acetonitrile at room temperature in high yields (Figure-26).
Figure-26
Nandkishor N. Karade et al. 57 has achieved oxidative dehydrogenation of 3,4-
dihydropyrimidin-2(1H)-ones to 1,2-dihydropyrimidines through a novel combination
of (diacetoxyiodo)benzene and tert-butylhydroperoxide in CH 2 Cl 2 (Figure-27).
Figure-27
Kana Yamamoto et al. 58 has reported method for oxidative dehydrogenation of
dihydropyrimidinones and dihydropyrimidines by using catalytic amounts of a Cu
salt, K 2 CO 3 , and tert-butylhydroperoxide (TBHP) as a terminal oxidant (Figure-28).
Figure-28
Synthetic Methods for the Synthesis of 2-Chloropyrimidine Derivatives
Several methods were reported in the literature for the chlorination of 2-
hydroxypyrimidines, few of them are described herein.
Driwedi Shriprakash Dhar et al. 59 has reported synthesis of 2-halopyrimidine
derivative from 2-hydroxypyrimidine by using thionyl chloride and dimethyl
formamide and toluene as a solvent at 80 o C (Figure-29).
Department of Chemistry, Saurashtra University, Rajkot-360005 14