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Chapter 6 Synthesis of benzodiazepines The newly synthesized compounds ADZ-04a-j were conformed on the basis of their elemental analysis and spectral data (MS, IR, 1 H NMR and 13 C NMR). The structure of ADZ-04a was supported by its mass (m/z 268) which agree with its molecular formula C 16 H 13 FN 2 O, its 1 H NMR spectrums held a singlet at δ =3.42 ppm assigned to -CH 3 , two doublet signals observed at δ =3.75-3.78 (1H, J=10.5Hz) and 4.78-4.81 (1H, J=10.5Hz) assigned to –CH 2 group, and four multiplet signal observed at δ =7.05-7.65 assigned to the aromatic protons. All synthesized compounds ADZ-05a-j were conformed on the basis of their elemental analysis and spectral data (MS, IR, 1 H NMR and 13 C NMR).The analytical data for ADZ-05a revealed a molecular formula C 22 H 15 FN 2 O(m/z 342). Its 1 H NMR signals held at δ = 6.39 (s. 1H, CH), 7.08-7.12 (m, 1H, Ar), 7.21-7.37 (m, 7H, Ar), 7.46-7.53 (m, 3H, Ar), 7.76-7.79 (m, 2H, Ar), 8.15 (s, 1H, -CONH). Department of Chemistry, Saurashtra University, Rajkot-360005 214
Chapter 6 Synthesis of benzodiazepines 6.7 Conclusion In summary, we have demonstrated a simple and effective strategy for the synthesis of novel1-and 3-substituted 1,4-benzodiazepines. The reaction of 1,4- benzodiazepines either with various alkyl halide or a variety of aromatic aldehydes in the presence of potassium hydroxide afforded the desired 1-and 3-substituted 1,4- benzodiazepine derivatives (ADZ-04a-j and ADZ-05a-j) in excellent yields. Department of Chemistry, Saurashtra University, Rajkot-360005 215
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Saurashtra University Re - Accredit
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Statement under O.Ph.D.7 of Saurash
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I am thankful to FIST/DST and SAP/U
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Chapter 4 Synthesis and Characteriz
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Chapter - 1 Palladium Catalyzed Syn
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