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Chapter-5
Synthesis of highly substituted pyrroles
After completion, the reaction mixture was cooled to rt, washed with water and 5 (%)
sodium bicarbonate solution. The organic layer was separated, dried over anhydrous
sodium sulfate and evaporated to dryness under reduce pressure. The residue was
crystallized from isopropyl alcohol/water (11:5) to obtain the desire product (68-85 %
yield).
‣ Microwave assisted method:
A flat bottom flask was charged with the 1,4 dicarbonyl compound (ADD-01-
30, 2 mmol), amino side chain (5, 2mmol), pivalic acid (2 mmol), cyclohexane (18
mL) and THF (2 mL). The reaction mixture was irradiated under microwave for
appropriate time (Table-2). The progress of reaction was monitored by thin layer
chromatography. After completion, the reaction mixture was cooled to and washed
with water, 5 % sodium bicarbonate solution. The organic layer was separated, dried
over anhydrous sodium sulfate and evaporated to dryness under reduce pressure. The
residue was crystallized from isopropyl alcohol/water (11:5) to obtain the desire
product (85-95 % yield).
Department of Chemistry, Saurashtra University, Rajkot-360005 179