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Chapter-5<br />
Synthesis of highly substituted pyrroles<br />
Antimicrobial Sensitivity Assay<br />
(Concentration 250/500/1000 µg/ml)<br />
Sr.<br />
No.<br />
CODE<br />
No.<br />
Pseudomonas<br />
aeruginosa<br />
Proteus vulgaris Escherichia<br />
coli<br />
Staphylococcus<br />
aureus<br />
Candida<br />
albicans<br />
250 500 1000 250 500 1000 250 500 1000 250 500 1000 250 500 1000<br />
1. AS-01 R R R R R R R R R R R R R R R<br />
2. AS-02 1.5 1.7 2.0 1.4 1.6 2.0 R R R R R R R R R<br />
3. AS-03 R R R R R R R R R R R R R 1.4 2.0<br />
4. AS-04 R 1.0 1.3 R R R R R R R R R R R R<br />
5. AS-05 R R 1.0 R R R R R R 1.1 1.4 2.0 1.1 1.5 2.0<br />
6. AS-06 R R R R R R 1.3 1.6 1.8 1.5 1.8 2.0 R R R<br />
7. AS-07 1.2 1.4 1.6 1.6 1.8 2.0 1.1 1.4 2.0 1.0 1.3 2.0 R R R<br />
8. AS-08 R R R R R R R 1.2 1.8 1.1 1.4 2.0 R R R<br />
9. AS-09 R R R R R R R R 1.2 R 1.3 2.0 R R R<br />
10. AS-10 1.0 1.3 1.7 R 1.0 1.5 R R 1.2 R R 1.2 1.3 1.8 2.0<br />
11. AS-11 R R R R R R R R R R R 1.2 R R R<br />
12. AS-12 R R R R R R 1.0 1.3 1.8 1.1 1.5 2.0 R R R<br />
13. AS-13 R R R R R R 1.6 1.8 2.0 1.4 1.6 2.0 1.0 1.4 2.0<br />
14. AS-14 R R R R R R R 1.2 1.8 1.1 1.4 2.0 1.1 1.5 2.0<br />
15. AS-15 R R R R R R R 1.1 1.7 R 1.3 2.0 1.5 1.8 2.0<br />
16. AS-16 1.6 1.8 2.0 1.0 1.2 1.6 R 1.1 1.6 1.2 1.5 1.7 R 1.1 1.8<br />
17. AS-17 R 1.4 2.0 1.0 1.3 1.5 1.2 1.5 2.0 1.3 1.5 2.0 1.5 1.7 2.0<br />
18. AS-18 1.0 1.3 1.5 1.1 1.3 1.6 1.5 1.8 2.0 1.5 1.7 2.0 R 1.5 1.9<br />
19. AS-19 1.2 1.5 1.8 1.5 1.8 2.0 1 1.2 2.0 1.1 1.6 2.0 1.3 1.6 2.0<br />
20. AS-20 R 1.3 1.0 1.1 1.3 1.2 1.0 1.2 1.4 1.0 1.2 1.5 1.2 1.5 1.7<br />
21. AS-21 R 1.4 2.0 R R R R R R R R R R R R<br />
22. AS-22 R 1.4 2.0 R R R 1.2 1.4 1.6 1.5 1.7 2.0 1.6 1.8 2.0<br />
23. AS-23 1.0 1.3 2.0 R R R R R R R R R R R R<br />
24. AS-24 R 1.4 2.0 R R R R R R R 1.0 1.3 R R R<br />
25. AS-25 R 1.3 2.0 R R R 1.1 1.4 2.0 R R 1.0 R R R<br />
26. AS-26 R R 1.2 R R R 1.1 1.4 2.0 R R R R R R<br />
27. AS-27 R R 1.2 1.5 1.8 2.0 1.0 1.3 2.0 R R 1.2 R 1.5 2.0<br />
28. AS-28 1.5 1.8 2.0 R 1.2 1.8 1.1 1.4 2.0 R R R R R R<br />
29. AS-29 R 1.4 2.0 R R 1.2 R 1.3 2.0 R R R R R R<br />
30. AS-30 R 1.4 2.0 R R 1.2 R R 1.2 R R R R R R<br />
31. A 1.8 1.8 1.9 1.9 -<br />
32. CPD 2.2 2.1 2.1 2.2 -<br />
33. GF 1.8 1.9 2.0 2.0 -<br />
34. GRF - - - - 2.6<br />
35. FLC - - - - 2.8<br />
Note: Zone of inhibition interpretation is as follows<br />
1. Zone size < 1.0 cm- Resistent (R)<br />
2. Zone size 1.0 to 1.5 cm – Intermediate<br />
3. Zone size > 1.5 – Sensitive<br />
STD Antibiotic Sensitivity Assay Concentration 40 µg/ml<br />
A: Ampicillin GRF: Gresiofulvin<br />
CPD: Cefpodoxime FLC: Fluconazole<br />
GF: Gatifloxacin<br />
Department of Chemistry, <strong>Saurashtra</strong> <strong>University</strong>, Rajkot-360005 175
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