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Chapter - 5 Rapid Synthesis of Highly Substituted Pyrrole Derivatives: Analogs of Atorvastatin
Chapter-5 Synthesis of highly substituted pyrroles 5.1 Introduction Pyrrole is an important π-excessive aromatic heterocycle because this ring system is incorporated in as a basic structural unit in porphyrins;porphin (heam) and chlorine (chlorophyll) and corrins (vitamin B12) (Figure-1). More over the presence of pyrrole ring in system in porphobilinogen (intermediate in biosynthesis of porphyrins and vitamin B12), biliverdin and bilirubin (pyrrole-based bile pigments) and pyrrolnitrin (with antibiotic activity) has provided an impetus to the pyrrole chemistry. Figure-1 Pyrrole has a planar pentagonal structure with four carbon atoms and nitrogen sp 2 -hybridized. Each ring atom forms two sp 2 -sp 2 σ -bonds to its neighbouring ring atoms and one sp 2 -sσ -bond to a hydrogen atom. The remaining unhybridized p- orbitals, one on each ring atom (with one electron on each carbon and two electron on nitrogen), are perpendicular to the plane of σ–bonds and overlap form a π-molecular system with three bonding orbitals. The six π-electrons form an aromatic sextet which is responsible for aromaticity and renders stability to the pyrrole ring. The C α -N and C α -C β bonds are shorter than normal single bonds, where as C α -C β bonds are normal than normal double bonds. The molecular dimentions of the pyrrole reflect cyclic delocalization with the environment of lone pair of electrons on the nitrogen atom. Department of Chemistry, <strong>Saurashtra</strong> <strong>University</strong>, Rajkot-360005 158
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Saurashtra University Re - Accredit
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Statement under O.Ph.D.7 of Saurash
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I am thankful to FIST/DST and SAP/U
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Chapter 4 Synthesis and Characteriz
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Chapter - 1 Palladium Catalyzed Syn
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pyrazole derivative were faster and
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Conferences participated 1. “15 t
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