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Chapter 4
Synthesis of highly substituted pyrazolopyrimidine
4.4 Current research work
The pyrazolopyrimidine derivatives have considerable chemical and
pharmacological importance because of a broad range of biological activities
displayed by these classes of molecules. As we demonstrated, the tremendous
biological potential of pyrazolopyrimidine derivatives encouraged us to synthesize
some new highly functionalized pyrazolopyrimidine derivatives. Various
methodologies have been described for the synthesis of pyrazolopyrimidine
derivatives. However, the existing methods are suffer with some drawbacks, such as;
yield, time, product isolation, isomer formation.
As a part of our ongoing interest on the synthesis of various heterocyclic
compounds using ketene dithioacetals, we have demonstrated that ketene dithioacetals
are versatile intermediate for the synthesis of pyrazolopyrimidine derivatives. Thus, to
explore further, we sought that the reaction of various ketene dithioacetals with 5-
amino-N-cyclohexyl-3-(methylthio)-1H-pyrazole-4-carboxamide in the presence of
base in isopropyl alcohol could be an effective strategy to furnish the novel
pyrazolopyrimidine derivatives. Here we describe the novel synthetic methodology
for the fused pyrazolopyrimidines.
Department of Chemistry, Saurashtra university, Rajkot-360005 132