Download (6Mb) - Etheses - Saurashtra University

Chapter 4
Synthesis of highly substituted pyrazolopyrimidine
Figure-21
Mohamed R. Shaaban et al. 37 have described a simple, facile, efficient and one
pot three-component procedure for the synthesis of pyrazolo[1,5-a]pyrimidine ring
systems incorporating phenylsulfonyl moiety was developed via the reaction of 1-
aryl-2-(phenylsulfonyl)ethanone derivatives with the appropriate heterocyclic amine
and triethylorthoformate (Figure-22).
Figure-22
Baseer M. Shaikh et al. 38 has prepared pyrazolo [1, 5-a] pyrimidines derivative by the
condensation of substituted of α, β- unsaturated carbonyl compounds (chalcones) with
substituted 5-aminopyrazole as an alternative polyethylene glycol (PEG-400) as green
reaction medium (Figure-23).
Figure-23
Department of Chemistry, Saurashtra university, Rajkot-360005 131