Download (6Mb) - Etheses - Saurashtra University

Chapter 3
Synthesis of trisubstituted pyrazoles/isoxazoles
3.7 Conclusion
In summary, we have synthesized a library of pyrazoles and isoxazoles
functionalized with cyclopropyl, thiomethyl and carboxamide moieties in single steps
with excellent yield under microwave irradiation. As a part of ‘green chemistry’
approach condensation reaction of various ketene dithioacetals with hydrazine hydrate
or hydroxyl amine hydrochloride in solvent free condition under microwave
irradiation. The present procedure is significant over the existing methods to develop
this class of molecules with excellent yield, purity and simple isolation of products.
Department of Chemistry Saurashtra university, Rajkot-360005 100