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Translocation by CryoEM<br />
Update for translocation model<br />
EF-G+GTP<br />
binding<br />
GTP hydrolysis<br />
and Pi release<br />
E P A<br />
E P A<br />
E P A<br />
L1<br />
L1<br />
EF-G<br />
GTP<br />
L1<br />
EF-G<br />
GDP<br />
E<br />
P<br />
A<br />
E<br />
P<br />
A<br />
E*<br />
P*<br />
A*<br />
Unlocked<br />
•Translocation on the 50S first (hybrid tRNAs)<br />
•Relative rotation between subunits<br />
•L1 stalk holds the mRNA-(tRNAs) complex<br />
•EF-G changes recover ground state<br />
Locked
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