Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev
Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev
3 MACERATION, PERCOLATION AND INFUSION TECHNIQUES FOR THE EXTRACTION OF MEDICINAL AND AROMATIC PLANTS 3.5.4.2.1 Advantages The crude drug is extracted as many times as there are receivers (in Figure 2 there are three receivers). If more extraction stages are required, it is only necessary to have more receivers. The last treatment of the drug – before it is discharged – is with fresh solvent, giving maximum extraction. The solution is in contact with fresh drug before removal for evaporation, giving the highest possible concentration. 3.5.4.2.2 Procedure Fill the extractor with crude drug, add solvent and circulate. Run off to receiver 1. Refi ll the extractor with solvent and circulate. Run off to receiver 2. Refi ll the extractor with solvent and circulate. Run off to receiver 3. Remove drug from the extractor and recharge. Return solution from receiver 1 to the extractor. Remove for evaporation. Return solution from receiver 2 to the extractor and circulate. Run off to receiver 1. Return solution from receiver 3 to the extractor and circulate. Run off to receiver 2. Add fresh solvent to the extractor and circulate. Run off to receiver 3. Remove drug from the extractor and recharge. Repeat cycle. 3.5.4.2.3 Extraction Battery Figure 2: Multistage extraction In the normal percolation process, the percolate is a very dilute solution, while the ideal situation is to obtain the maximum concentration possible. Continuous extraction devices of battery type are used when large amounts of a single material are handled. Such devices can be achieved by treating percolation as a multistage process. In an extraction battery process, a series of vessels is used and extraction is semicontinuous. 3.5.4.2.4 Equipment An extraction battery consists of a number of vessels with interconnecting piping. Vessels are so arranged that solvent can be added to and the product taken from any vessel. These vessels can, therefore, be 74
EXTRACTION TECHNOLOGIES FOR MEDICINAL AND AROMATIC PLANTS made into a series with any of vessels as the fi rst of the series. The use of an extraction battery is illustrated in Figure 3, which shows the simplest arrangement of three vessels. 1. 2. 3. 4. 5. 6. S 4 3 2 F 1 A B C 3 2 A B C E 4 P 1 2 F 1 S 4 3 A B C 2 3 A B C P 1 E 4 3 2 F 1 S 4 A B C 3 2 A B C P 1 E 4 1. 2. 3. 4. 1. 2. 3. 4. 1. 2. 3. 4. 1. 2. 3. 4. 1. 2. 3. 4. 1. 2. 3. 4. Figure 3: Extraction battery 3.6 Percolation (Exhaustive Extraction) 3.6.1 General Process of Percolation In this process, an organized vegetable drug, in a suitably powdered form, is packed in a percolator and the solvent is allowed to percolate through it. Although some materials (e.g. ginger) may be packed directly into the percolator in a dry state, this may cause difficulties with other drugs. With the addition of solvent, the dry material swells and this swelling increases with increasing aqueous nature of the solvent. This swelling reduces or blocks the flow of the solvent, thus seriously affecting the extraction process. Fur- 75
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EXTRACTION TECHNOLOGIES FOR MEDICINAL AND AROMATIC PLANTS<br />
made into a series with any of vessels as the fi rst of the series. The use<br />
of an extraction battery is illustrated in Figure 3, which shows the simplest<br />
arrangement of three vessels.<br />
1.<br />
2.<br />
3.<br />
4.<br />
5.<br />
6.<br />
S 4 3 2 F 1<br />
A B C<br />
3 2<br />
A B C<br />
E 4<br />
P 1<br />
2 F 1 S 4 3<br />
A B C<br />
2<br />
3<br />
A B C<br />
P 1 E 4<br />
3 2 F 1 S 4<br />
A B C<br />
3 2<br />
A B C<br />
P 1 E 4<br />
1. <br />
2. <br />
3. <br />
4. <br />
1. <br />
2. <br />
3. <br />
4. <br />
1. <br />
2. <br />
3. <br />
4. <br />
1. <br />
2. <br />
3. <br />
4. <br />
1. <br />
2. <br />
3. <br />
4. <br />
1. <br />
2. <br />
3. <br />
4. <br />
<br />
<br />
<br />
<br />
Figure 3: <strong>Extraction</strong> battery<br />
3.6 Percolation (Exhaustive <strong>Extraction</strong>)<br />
3.6.1 General Process of Percolation<br />
In this process, an organized vegetable drug, in a suitably powdered<br />
<strong>for</strong>m, is packed in a percolator <strong>and</strong> the solvent is allowed to percolate<br />
through it. Although some materials (e.g. ginger) may be packed directly into<br />
the percolator in a dry state, this may cause difficulties with other drugs. With<br />
the addition of solvent, the dry material swells <strong>and</strong> this swelling increases<br />
with increasing aqueous nature of the solvent. This swelling reduces or blocks<br />
the flow of the solvent, thus seriously affecting the extraction process. Fur-<br />
75