Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev
Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev
5 DECOCTION AND HOT CONTINUOUS EXTRACTION TECHNIQUES 5.7 Accelerated Solvent Extraction 5.7.1 Principles and Mechanisms Accelerated solvent extraction (ASE) is a solid-liquid extraction process performed at elevated temperatures, usually between 50° and 200° C, and at pressures between 10 and 15 MPa. Therefore, accelerated solvent extraction is a form of pressurized solvent extraction. Increased temperature accelerates the extraction kinetics and elevated pressure keeps the solvent in the liquid state, thus achieving safe and rapid extraction. Also, high pressure allows the extraction cell to be fi lled faster and helps to force liquid into the solid matrix. A typical accelerated solvent extraction system is illustrated in Figure 11. Although the solvent used in ASE is usually organic, pressurized hot water can also be used. In these cases, one refers to pressurized hot water extraction or sub-critical water extraction. Figure 11: Accelerated solvent extraction 5.7.2 Advantages and Disadvantages of Accelerated Solvent Extraction Compared with traditional Soxhlet extraction, ASE presents a dramatic reduction in the amount of solvent and extraction time. Particular attention should be paid to ASE performed at high temperature, which may lead to degradation of thermolabile compounds. 5.8 Important Factors for Designing a Solvent Extraction Plant for Medicinal Plants • High effi ciency of extraction • Minimal solvent loss • Facilities for cold and hot extractions • Extraction with agitation 104
EXTRACTION TECHNOLOGIES FOR MEDICINAL AND AROMATIC PLANTS • Multiple solvent extraction systems • Multiple fraction collection systems • On-line fi ltration unit • Solvent recycling and condensing unit • Vent lines with breather for minimizing solvent loss and maximizing safety • Brine circulation unit • Fractionating column for separation of solvent mixtures • Effi cient evaporating systems like falling fi lm, wiped fi lm or rotary evaporators to work under low pressures • Vacuum manifold system with cold traps • GMP compatible • Automation 5.9 Conclusions Figure 12: Solvent extraction plant at CIMAP, India Decoction, a water-based preparation, is one of the most used traditional methodologies for the extraction of active constituents of a medicinal plant. It is generally carried out by boiling the plant part for a fi xed period. Hot continuous extraction or solvent extraction technique is one of the most widely used extraction techniques for the processing of medicinal plants. The solvent extraction method is simple, well established and economical. Important factors that can affect the effi ciency of extraction, such as post-harvest processing, solid characteristics, choice of solvent, method of contact, and temperature, should be optimized for best yield. The choice of solvent especially for commercial plants and high effi ciency usually de- 105
- Page 57 and 58: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 59 and 60: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 61 and 62: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 63 and 64: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 65 and 66: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 67 and 68: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 69 and 70: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 71 and 72: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 73 and 74: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 75 and 76: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 77 and 78: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 79 and 80: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 81 and 82: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 83 and 84: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 85 and 86: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 87 and 88: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 89 and 90: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 91 and 92: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 93 and 94: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 95 and 96: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 97 and 98: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 99 and 100: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 101 and 102: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 103 and 104: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 105 and 106: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 107: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 111 and 112: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 113 and 114: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 115 and 116: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 117: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 120 and 121: 7 DISTILLATION TECHNOLOGY FOR ESSEN
- Page 122 and 123: 7 DISTILLATION TECHNOLOGY FOR ESSEN
- Page 124 and 125: 7 DISTILLATION TECHNOLOGY FOR ESSEN
- Page 126 and 127: 7 DISTILLATION TECHNOLOGY FOR ESSEN
- Page 128 and 129: 7 DISTILLATION TECHNOLOGY FOR ESSEN
- Page 130 and 131: 7 DISTILLATION TECHNOLOGY FOR ESSEN
- Page 133 and 134: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 135 and 136: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 137 and 138: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 139 and 140: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 141 and 142: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 143 and 144: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 145 and 146: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 147: EXTRACTION TECHNOLOGIES FOR MEDICIN
- Page 150 and 151: 9 SOLID PHASE MICRO-EXTRACTION AND
- Page 152 and 153: 9 SOLID PHASE MICRO-EXTRACTION AND
- Page 154 and 155: 9 SOLID PHASE MICRO-EXTRACTION AND
- Page 156 and 157: 9 SOLID PHASE MICRO-EXTRACTION AND
EXTRACTION TECHNOLOGIES FOR MEDICINAL AND AROMATIC PLANTS<br />
• Multiple solvent extraction systems<br />
• Multiple fraction collection systems<br />
• On-line fi ltration unit<br />
• Solvent recycling <strong>and</strong> condensing unit<br />
• Vent lines with breather <strong>for</strong> minimizing solvent loss <strong>and</strong> maximizing<br />
safety<br />
• Brine circulation unit<br />
• Fractionating column <strong>for</strong> separation of solvent mixtures<br />
• Effi cient evaporating systems like falling fi lm, wiped fi lm or<br />
rotary evaporators to work under low pressures<br />
• Vacuum manifold system with cold traps<br />
• GMP compatible<br />
• Automation<br />
5.9 Conclusions<br />
Figure 12: Solvent extraction plant at CIMAP, India<br />
Decoction, a water-based preparation, is one of the most used<br />
traditional methodologies <strong>for</strong> the extraction of active constituents of a medicinal<br />
plant. It is generally carried out by boiling the plant part <strong>for</strong> a fi xed<br />
period. Hot continuous extraction or solvent extraction technique is one of<br />
the most widely used extraction techniques <strong>for</strong> the processing of medicinal<br />
plants. The solvent extraction method is simple, well established <strong>and</strong> economical.<br />
Important factors that can affect the effi ciency of extraction, such<br />
as post-harvest processing, solid characteristics, choice of solvent, method<br />
of contact, <strong>and</strong> temperature, should be optimized <strong>for</strong> best yield. The choice<br />
of solvent especially <strong>for</strong> commercial plants <strong>and</strong> high effi ciency usually de-<br />
105