Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev

Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev Extraction Technologies for Medicinal and Aromatic ... - Capacity4Dev

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30.10.2014 Views

5 DECOCTION AND HOT CONTINUOUS EXTRACTION TECHNIQUES 5.7 Accelerated Solvent Extraction 5.7.1 Principles and Mechanisms Accelerated solvent extraction (ASE) is a solid-liquid extraction process performed at elevated temperatures, usually between 50° and 200° C, and at pressures between 10 and 15 MPa. Therefore, accelerated solvent extraction is a form of pressurized solvent extraction. Increased temperature accelerates the extraction kinetics and elevated pressure keeps the solvent in the liquid state, thus achieving safe and rapid extraction. Also, high pressure allows the extraction cell to be fi lled faster and helps to force liquid into the solid matrix. A typical accelerated solvent extraction system is illustrated in Figure 11. Although the solvent used in ASE is usually organic, pressurized hot water can also be used. In these cases, one refers to pressurized hot water extraction or sub-critical water extraction. Figure 11: Accelerated solvent extraction 5.7.2 Advantages and Disadvantages of Accelerated Solvent Extraction Compared with traditional Soxhlet extraction, ASE presents a dramatic reduction in the amount of solvent and extraction time. Particular attention should be paid to ASE performed at high temperature, which may lead to degradation of thermolabile compounds. 5.8 Important Factors for Designing a Solvent Extraction Plant for Medicinal Plants • High effi ciency of extraction • Minimal solvent loss • Facilities for cold and hot extractions • Extraction with agitation 104

EXTRACTION TECHNOLOGIES FOR MEDICINAL AND AROMATIC PLANTS • Multiple solvent extraction systems • Multiple fraction collection systems • On-line fi ltration unit • Solvent recycling and condensing unit • Vent lines with breather for minimizing solvent loss and maximizing safety • Brine circulation unit • Fractionating column for separation of solvent mixtures • Effi cient evaporating systems like falling fi lm, wiped fi lm or rotary evaporators to work under low pressures • Vacuum manifold system with cold traps • GMP compatible • Automation 5.9 Conclusions Figure 12: Solvent extraction plant at CIMAP, India Decoction, a water-based preparation, is one of the most used traditional methodologies for the extraction of active constituents of a medicinal plant. It is generally carried out by boiling the plant part for a fi xed period. Hot continuous extraction or solvent extraction technique is one of the most widely used extraction techniques for the processing of medicinal plants. The solvent extraction method is simple, well established and economical. Important factors that can affect the effi ciency of extraction, such as post-harvest processing, solid characteristics, choice of solvent, method of contact, and temperature, should be optimized for best yield. The choice of solvent especially for commercial plants and high effi ciency usually de- 105

EXTRACTION TECHNOLOGIES FOR MEDICINAL AND AROMATIC PLANTS<br />

• Multiple solvent extraction systems<br />

• Multiple fraction collection systems<br />

• On-line fi ltration unit<br />

• Solvent recycling <strong>and</strong> condensing unit<br />

• Vent lines with breather <strong>for</strong> minimizing solvent loss <strong>and</strong> maximizing<br />

safety<br />

• Brine circulation unit<br />

• Fractionating column <strong>for</strong> separation of solvent mixtures<br />

• Effi cient evaporating systems like falling fi lm, wiped fi lm or<br />

rotary evaporators to work under low pressures<br />

• Vacuum manifold system with cold traps<br />

• GMP compatible<br />

• Automation<br />

5.9 Conclusions<br />

Figure 12: Solvent extraction plant at CIMAP, India<br />

Decoction, a water-based preparation, is one of the most used<br />

traditional methodologies <strong>for</strong> the extraction of active constituents of a medicinal<br />

plant. It is generally carried out by boiling the plant part <strong>for</strong> a fi xed<br />

period. Hot continuous extraction or solvent extraction technique is one of<br />

the most widely used extraction techniques <strong>for</strong> the processing of medicinal<br />

plants. The solvent extraction method is simple, well established <strong>and</strong> economical.<br />

Important factors that can affect the effi ciency of extraction, such<br />

as post-harvest processing, solid characteristics, choice of solvent, method<br />

of contact, <strong>and</strong> temperature, should be optimized <strong>for</strong> best yield. The choice<br />

of solvent especially <strong>for</strong> commercial plants <strong>and</strong> high effi ciency usually de-<br />

105

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