easy-graft®CLASSIC - Degradable Solutions AG

easy-graft ® CLASSIC
injectable
insitu hardening
100% synthetic bonegraft
bionic sticky granules

A success story from
the start-up to a
specialist for bone
graft biomaterials
Together with leading dentists of the University of
Zurich and experts in the field of biomaterials at ETH
Zurich, we started in 1999 to develop a new therapy
with the aim to prevent the atrophy of the alveolar
crest after tooth extraction.
First, we developed a phase pure ß-Tricalciumphosphate
(ß-TCP) granulate for bone defect filling:
calc-i-oss. Its high interconnected porosity, superior
purity and histological prove of complete resorption
is highly valued by the users.
Thereafter, we succee -
ded in coating the granules
with a micro-meter
thick layer of polylactic
acid. This allows the
user to glue the granules
together. Thus, our
product RootReplica
was born. This exact
copy of the extracted
tooth root made from a
resorbable bone graft stops post extraction bleeding,
prevents the loss of the coagulum and maintains
the alveolar ridge in both height and width. This
therapy creates the optimal condition for any subsequent
prosthetic treatment.
Our newest achievement is the development of
our “Biolinker” – an activator which transforms the
coated granules into a sticky mass and thus allows
the bone graft to be applied directly from its syringe
to the defect. In contact with blood the biomaterial
solidifies and forms a defect-analog, mechanically
stable, but porous solid body, which will be replaced
over time with bone tissue. We call our product easygraft:
there is no “easier” way to fill bone defects.
easy-graft bases on our long term experience in developing
bone graft materials. It allows the user to
treat bone defects in periodontology, oral surgery,
implantology and after tooth extraction in the most
simple and fastest way imaginable. Just try it out!
I hope I was able to spark your interest in our biomaterials.
Thank you for your trust in our products.
Faithfully yours,
High clinical benefits due to an innovative biomaterial concept
• Osteo-regeneration and complete resorption of
graft due to phase pure ß-Tricalciumphosphate
• Ingrowth of cells due to interconnected open
porosity
• High porosity due to bionic structure of
granules
• Injectable putty due to fast resorbing
polylactic acid coating
• Prevention of bacterial colonialisation due to
dense coating
• No loss of granules due to solid body
formation in situ
• Blood uptake and tissue ingrowth due to
porosity between granules
• Hemostyptic effect
• High biocompatibility demonstrated in
histologic sections
Dr. Kurt Ruffieux
CEO Degradable Solutions AG
• Direct bone contact promotes tissue ingrowth
• Bone formation in parallel to graft degradation

Socket preservation
• Clean defect using indication specific standard procedure
• Inject easy-graft ® CLASSIC from the syringe into the defect
• Mold the sticky granules to fill the defect with a condenser
• Excess granules may be removed easily with a scaler
• Suture the wound as well as the indication allows.

Easy to use: mix – apply
easy-graft ® CLASSIC consists of the
unique biomaterial: bioceramic granules
with a sticky surface. Apply directly into
the defect, the bone graft will harden in
situ within minutes...
Step by step...
Open the pouch with the syringe
containing easy-graft ® CLASSIC granules,
open the pouch with the Biolinker.
Fill the Biolinker into the syringe.
Mix both components and discard
excess Biolinker.
The granules are now sticky and may
be applied directly into the bone defect.
Literatur about DS Biomaterials
Reichhardt, D. et al. 2006. Injectable and PLGA coated β-TCP granules hardening in situ: an in vitro
study. Swiss Conference on Biomaterials, May 10th. - Thoma, K. et al. 2006. Bioabsorbable root analogue
for closure of oroantral communications: A prospective case report. Oral Surg Oral Med Oral
Pathol Oral Radiol Endod, in press. - Nair, R. et al. 2006. Biocompatibility of β-Tricalcium Phosphate
Root Replicas in Porcine Tooth Extraction Sockets – A Correlative Histological, Ultrastructural, and
X-ray Microanalytical Pilot Study. Biomaterials Applications, 0: 1-18, Jan 27.- Nair, R. et al. 2004.
Observations on healing of human tooth extraction sockets implanted with bioabsorbable polylacticpolyglycolic
acids (PLGA) copolymer root replicas: A clinical, radiographic and histological follow-up
report of 8 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 97: 559-69, May. - Nair, R.
et al. 2004. β-TCP/PLGA open porous scaffolds for the prevention of alveolar bone loss after tooth
extraction: Evaluation in a mini-pig model. World Biomaterials Congress, May 17-21. - Maspero,
FA, Ruffieux, K. 2004. β-TCP/PLGA open porous scaffolds for the prevention of alveolar bone loss
after tooth extraction: scaffold characterization and in vitro degradation behaviour. World Biomaterials
Congress, May 17-21. - Reichhardt, D., Ruffieux, K. 2004. Supporting Literature and References for
calc-i-oss and calc-i-oss Ortho. TM-056, Dec 14. - Schmidlin, P. et al. 2004. Alveolarkammprävention
nach Zahnextraktion – eine Literaturübersicht, Schweiz Monatsschr Zahnmed, 114: 328-336, April.
Schugg, J. et al. 2002. Prävention der Alveolarkammatrophie nach Zahnextraktion durch Wurzelreplikas.
DZW, 47: 14-15, Feb. - Maspero, FA et al. 2002. Resorbable defect analog PLGA scaffolds using
C02 as solvent: Structural characterization, J Biomed Mater Res, 62: 89-98. - Heidemann, W. et al.
2001. Degradation of poly(D,L)lactide implants with or without addition of calciumphosphates in vivo.
Biomaterials, 22: 2371-2381. - Maspero, FA et al. 1999. Comparisons of the Degradation Behavior
of two Open Porous PLGA-Scaffolds, Tissue Engineering Congress. - Suhonen, J., Meyer, B. 1996.
Polylactic acid (PLA) root replica in ridge maintenance after loss of a vertically fractured incisor. Endod
Dent Trumatol, 12: 155-160. - Suhonen, J. et al. 1995. Custom made Polyglycolic acid (PGA)-root
replicas placed in extraction sockets of rabbits. Dt. Z Mund Kiefer Gesichts Chir. 19: 253-257.
bionic sticky granules

Simplify your therapy
Straight from the syringe into the defect ...
easy-graft ® CLASSIC is the first biomaterial
applied straight from the syringe into the defect
where it subsequently hardens and creates
a porous but stable bone graft. During the
application the granules stick together and stay
at the defect site.
easy-graft ® CLASSIC is 100 % synthetic,
completely resorbable and replaced by autologeous
bone tissue within months.
easy-graft ® CLASSIC is intended for use
for all dental indications where bone grafts are
needed.
benefits in periodontology
• easy modelling in the pocket
• the sticky granules stay in the defect
• no membrane needed
• insitu hardening
• reduction of pocket depth from 7up to 2 mm!

easy-graft ® CLASSIC
Product easy-graft ® 150 easy-graft ® 400
Reference no. C11-012 C11-013 C11-002 C11-003
Units 3 x 0.15 ml 6 x 0.15 ml 3 x 0.4 ml 6 x 0.4 ml
Granule size 500 – 630 µm 500 – 630 µm 500 – 1’000 µm 500 – 1’000 µm
Material Pure phase ß-tricalcium phosphate (>99 %)
Indication
Small defects in oral surgery, implantology, socket preservation, and sinus
floor elevation
easy-graft ® CRYSTAL
Reference no. C15-012 C15-013 C15-002 C15-003
Units 3 x 0.15 ml 6 x 0.15 ml 3 x 0.4 ml 6 x 0.4 ml
Granule size 450 – 630 µm 450 – 630 µm 450 – 1’000 µm 450 – 1’000 µm
Material
Indication
Biphasic calcium phosphate (60 % HA / 40 % ß-TCP)
Large bone defects and patients with reduced bone regeneration potential,
e.g. in cystectomy, socket preservation, sinus floor elevation, bone spreading,
guided bone regeneration (GBR), periodontal defects, periimplantitis
calc-i-oss ®
Reference no. A02-103B A02-103C A02-103D
Units 3 x 0.5 g 3 x 1.0 g 3 x 2.0 g
Granule size 315 – 500 µm 500 – 1’000 µm 1’000 – 1‘600 µm
Material Pure phase ß-tricalcium phosphate (>99%)
Indication
General bone defects in oral surgery and implantology
RootReplica
The leading product against atrophy of the alveolar ridge after tooth extraction
Recommended indications: Alveoles therapy after tooth extraction
RootReplica TM Implant Kit Set of 3 Implants incl. Impression material
3 scalpels, biomaterial (granules + membrane)
Reference number C 01- 003
RootReplica TM Equipment Kit Replicator, heated Condenser, Impression gun
Reference number F 07- 01005
Degradable Solutions AG
Wagistrasse 23
CH-8952 Schlieren/Zurich
Phone +41 43 433 62 60
Fax +41 43 433 62 61
www.degradable.ch
dental@degradable.ch