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For example, pivampicillin and pivmecillinam, and any other combinations including two or<br />
more active ingredients belonging to QJ01CA - Penicillins with extended spectrum, are<br />
given the ATCvet code QJ01CA20.<br />
Combinations of substances used exclusively in veterinary medicine have been given the 5th<br />
level code 99.<br />
Separate ATCvet 3rd or 4th level codes have been assigned to certain important combinations,<br />
e.g. QJ51R - Combinations of antibacterials for intramammary use.<br />
The main therapeutic use decides which ATCvet code is to be used. A product containing<br />
vitamins and iron used primarily as an iron product should be classified in QB03 - Antianemic<br />
preparations. Likewise, a product containing vitamins and antibiotics should be assigned to QJ -<br />
Antiinfectives for systemic use.<br />
The sequence of classification codes of combination products should as far as possible agree<br />
with the order of classification of the single substances in question. In some ATCvet groups a<br />
ranking is needed to help in the classification of combination products (e.g. in QN02B and<br />
QJ51R). This ranking shows which substances take precedence over others when the<br />
classification is decided.<br />
3. Procedures and data requirements for ATCvet classifications and<br />
alterations<br />
3.1 Classification of new substances and data requirements<br />
Requests for classifications of new substances should be addressed to the WHO Collaborating<br />
Centre for Drug Statistics Methodology. It is recommended that requests be made using the<br />
special application form obtainable from the Centre (see Annex 1) or our website at<br />
www.whocc.no.<br />
A new medicinal substance is normally not included in the ATC system before an application for<br />
marketing authorisations is submitted in at least one country. In some cases, it may be necessary<br />
to await a classification until the new substance has been approved in at least one country<br />
(especially for substances where it is considered difficult to establish a new 5th level). These<br />
conditions are set to avoid including in the ATC system too many substances which never<br />
become marketed.<br />
Data requirements:<br />
The following data should be submitted when requesting an ATCvet code for a substance:<br />
- Chemical structure and relationship to similar drugs.<br />
- Pharmacology and mechanism of action, including relationship to similar drugs.<br />
- Main indication.<br />
- Other indications.<br />
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