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QJ01D
OTHER BETA-LACTAM ANTIBACTERIALS
Beta-lactam antibacterials other than penicillins are classified in this group.
The cephalosporins are classified into subgroups according to generations. The
reference applied when defining generations is “Principles and Practice of
Infectious Diseases” by Mandell, Douglas and Benett, sixth edition, 2005. For the
definitions used in this textbook, see under QJ01DB, QJ01DC, QJ01DD and
QJ01DE.
QJ01DB
First-generation cephalosporins
The first generation compounds have relatively narrow spectrum of activity focused
primarily on the gram-positive cocci.
QJ01DC
Second-generation cephalosporins
The second generation cephalosporins have a variable activity against gram-positive
cocci but have increased activity against gram-negative bacteria. The cephamycin
group is included here.
QJ01DD
Third-generation cephalosporins
The third generation cephalosporins have a marked activity against gram-negative
bacteria. Limited activity against gram-positive cocci, particularly methicillin
susceptible S. aureus, might occur.
QJ01DE
Fourth-generation cephalosporins
The fourth generation cephalosporins have activity against gram-positive cocci and
a broad array of gram-negative bacteria, including P. aeruginosa and many of the
Enterobacteriaceae with inducible chromosomal β-lactamases.
QJ01DF
Monobactams
Arginin and lysine salts of aztreonam are classified in QJ01DF01; thus aztreonam
for inhalation is classified together with systemic formulations.
QJ01DH
Carbapenems
Combinations with enzyme inhibitors are classified at separate 5th levels, using the
50-series.
QJ01DI
Other cephalosporins
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