Drug Dosing in Renal Insufficiency - Philippine College of Physicians
Drug Dosing in Renal Insufficiency - Philippine College of Physicians
Drug Dosing in Renal Insufficiency - Philippine College of Physicians
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Volume <strong>of</strong> distribution (V d ) <strong>in</strong> CKD<br />
• Increased V d<br />
Edema and ascites<br />
Hypoalbum<strong>in</strong>emia<br />
Potentially decrease<br />
plasma drug levels <strong>of</strong><br />
water-soluble and<br />
prote<strong>in</strong>-bound drugs<br />
• Decreased V d<br />
Muscle wast<strong>in</strong>g<br />
Volume depletion<br />
Potentially <strong>in</strong>crease<br />
plasma drug levels <strong>of</strong><br />
water-soluble drugs