Drug Dosing in Renal Insufficiency - Philippine College of Physicians
Drug Dosing in Renal Insufficiency - Philippine College of Physicians
Drug Dosing in Renal Insufficiency - Philippine College of Physicians
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Bioavailability <strong>in</strong> <strong>Renal</strong> <strong>Insufficiency</strong><br />
• Decreased drug absorption<br />
Nausea and vomit<strong>in</strong>g<br />
Alkal<strong>in</strong>iz<strong>in</strong>g effect <strong>of</strong> salivary urea<br />
Use <strong>of</strong> PPIs and H 2 -receptor blockers<br />
Use <strong>of</strong> phosphate b<strong>in</strong>ders<br />
Gut edema<br />
Bacterial colonization<br />
Altered <strong>in</strong>test<strong>in</strong>al motility<br />
• Altered hepatic first-pass metabolism
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