Drug Dosing in Renal Insufficiency - Philippine College of Physicians
Drug Dosing in Renal Insufficiency - Philippine College of Physicians
Drug Dosing in Renal Insufficiency - Philippine College of Physicians
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<strong>Drug</strong> dos<strong>in</strong>g considerations for PD<br />
• Perform antibiotic load<strong>in</strong>g by an extended cycle<br />
<strong>in</strong> CAPD and APD<br />
• Transperitoneal<br />
For most drugs<br />
drug<br />
<strong>in</strong> cl<strong>in</strong>ical<br />
movement<br />
use,<br />
may<br />
there<br />
be<br />
is<br />
less<br />
little<br />
effective <strong>in</strong> the acute phase <strong>of</strong> peritoneal<br />
evidence <strong>in</strong>fection when <strong>of</strong> significant <strong>in</strong>flammation-related drug removal capillary dur<strong>in</strong>g<br />
hyperperfusion subsides chronic PD.<br />
• Short dwell times <strong>in</strong> APD may prevent<br />
accumulation <strong>of</strong> antibiotic <strong>in</strong> the peritoneal<br />
cavity.<br />
• Monitor<strong>in</strong>g <strong>of</strong> drug blood levels is advocated.<br />
KDIGO 2011
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