Drug Dosing in Renal Insufficiency - Philippine College of Physicians
Drug Dosing in Renal Insufficiency - Philippine College of Physicians
Drug Dosing in Renal Insufficiency - Philippine College of Physicians
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Calculat<strong>in</strong>g <strong>in</strong>dividualized regimen<br />
• Dettli’s proportionality rules:<br />
If dos<strong>in</strong>g <strong>in</strong>terval unchanged, AUC same but<br />
with higher trough values—may prompt<br />
physician to wrongly lower the dose<br />
Implies absurdly low doses or wide <strong>in</strong>tervals<br />
between doses