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PTCA vs oefentherapie 37.Hambrecht. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease. Circulation 2004;109:1371-8 Design N/n Population Sd Interventions Outcomes Results RCT N=101 -Class I to III angina pectoris -100% male -≤ 70 years -Stable coronary artery disease (coronary angiography) -40-50% previous MI -Exclusion: recent MI, important left main coronary artery or left anterior descending stenosis, reduced left ventricular function, smoking, insulin dependent diabetes 12 m -Exercise training (20 minutes of becycle ergometry per day + 60 minute group training session of aerobic exercise) -PCI with stent Event-free survival* Amelioration in angina class Exercise parameters 88% vs 70% (PCI); p=0.023 No difference Better in exercise group Both + medical treatment Event= death of cardiac cause, stroke, resuscitation after cardiac arrest, CABG, angioplasty and worsening angina with objective evidence that resulted in hospitalization. Legend _ _ _ _ : exercise group ______: PCI months
- Oefentherapie - • Vs “usual therapy” na ≥ 6 m: –Oefentherapie ↓ mortaliteit met 20% Gami. Clinical Evidence 2007 •Vs PTCA (subgroep met lager risico) –Oefentherapie • ↑ event-free survival na 1 jaar (88 vs 70%) • = effect op angor • Parameters inspanningsproef verbeterd www.<strong>farmaka</strong>.be Project Farmaka
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Projekt Farmaka vzw Centrum voor on
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Hoe? 1. Van een klinisch probleem n
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Aanpak van stabiele angor www.farma
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Definitie en epidemiologie www.farm
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Natuurlijk verloop www.farmaka.be P
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Doelstelling van de behandeling www
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Acute behandeling www.farmaka.be Pr
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Anti-anginosa (onderhoudsbehandelin
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ANTIANGINOSA (niet in België) - we
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β-blokkers Niet-selectieve β-blok
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NITRATEN Sublinguaal Posologie Isos
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β-blokkers 17.Pepine. The atenolol
Page 26 and 27: β-blokkers Preserved ventricular f
Page 28 and 29: β-blokkers Helfand 2007 www.farmak
Page 30 and 31: - β-blokkers - • Mortaliteit en
Page 32 and 33: Calcium-antagonisten Gami P. Second
Page 34 and 35: • Werkzaam op angor - Calciumanta
Page 36 and 37: Nitraten 25.Heidenreich. JAMA 1999;
Page 38 and 39: - Molsidomine - • Werkzaamheid op
Page 40 and 41: - Trimetazidine, ranolazine, nicora
Page 42 and 43: - Combinaties en werkzaamheid angor
Page 44 and 45: Anti-anginosa - ongewenste effecten
Page 50 and 51: Invasieve behandeling www.farmaka.b
Page 52 and 53: - Aanvullende medicatie bij PCI -
Page 54 and 55: www.farmaka.be Project Farmaka
Page 56 and 57: - Terminologie invasieve ingrepen -
Page 58 and 59: PTCA vs enkel medicatie 53.Borzak.
Page 60 and 61: - PTCA vs enkel medicatie - • Bej
Page 62 and 63: - CABG vs enkel medicatie - • ↓
Page 64: -Stents - Bedoeling stents en DES:
Page 67 and 68: - CABG vs PTCA - • CABG: meer CVA
Page 69 and 70: Onderhoudsbehandeling Globale CV pr
Page 71 and 72: Rookstop Gami P. Secondary preventi
Page 73 and 74: Mediterraan dieet 1.Gami P. Seconda
Page 75: Oefentherapie 77. Gami P. Secondary
Page 79 and 80: - Stressmanagement - • Mogelijk
Page 81 and 82: - β-blokkers - Zie hoger www.farma
Page 83 and 84: Anti-aggregantia - ASA Gami P. Seco
Page 85 and 86: Consensusvergadering angor 2006. Di
Page 87 and 88: Anti-aggregantia - Ticlopidine en
Page 89 and 90: ACE-inhibitoren • Bij hoogrisicop
Page 91 and 92: - Sartanen - • Ramipril vs telmis
Page 93 and 94: -Statines - • ↓ mortaliteit en
Page 95 and 96: - Kernboodschappen - Patiënt met s
Page 97 and 98: - Symptomatische behandeling - •
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