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has led to a lot of paternalism. I am sure that <strong>in</strong> the<br />

breast cancer community that has been an issue to which a<br />

great deal of thought and writ<strong>in</strong>g has occurred but it is<br />

someth<strong>in</strong>g to keep <strong>in</strong> m<strong>in</strong>d here and it came through <strong>in</strong> your<br />

comments also about the pathologists. The sense that I<br />

have a resource, I want to do good, I want to determ<strong>in</strong>e<br />

what happens with it.<br />

The second is a phrase that you used about the<br />

tragedy of not do<strong>in</strong>g research and it is here that I want to<br />

<strong>in</strong>voke Jonas' ghost because I still am conv<strong>in</strong>ced by his<br />

view that the greatest tragedy is do<strong>in</strong>g th<strong>in</strong>gs which end up<br />

harm<strong>in</strong>g or wrong<strong>in</strong>g people <strong>in</strong> the name of the greater good<br />

of progress and that progress <strong>in</strong> his phrase is an optional<br />

good and it is a good which ought not to be bought at<br />

certa<strong>in</strong> other costs which can occur even <strong>in</strong> well<br />

<strong>in</strong>tentioned circumstances. Now obviously he was not -- his<br />

was not an argument for do<strong>in</strong>g noth<strong>in</strong>g but it is a question<br />

of what presumption we go <strong>in</strong>to th<strong>in</strong>gs with and <strong>in</strong> that l<strong>in</strong>e<br />

I would like to put four po<strong>in</strong>ts to you and ask you to<br />

elaborate on them because they were so <strong>in</strong>trigu<strong>in</strong>g as you<br />

went along.<br />

The first one was the notion that with some of<br />

this research, particularly I guess on retrospective<br />

research but maybe it went to both, public confidence was

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