Diabetes in pregnancy: are we providing the best care ... - HQIP

Diabetes in pregnancy: are we providing the best care ... - HQIP Diabetes in pregnancy: are we providing the best care ... - HQIP

25.10.2014 Views

A description of women and babies in the enquiry Table 5.2 Specifi c diabetes complications in women in the enquiry Specific diabetes complication Women in the enquiry n/N (%) Recurrent hypoglycaemia during pregnancy 203/400 (51) Hypoglycaemia requiring external help 63/311 (20) Pre-existing retinopathy 73/316 (23) New retinopathy 29/316 (9) Nephropathy 42/359 (12) 5.3 The babies 5.3.1 Pregnancy outcomes The outcomes of all pregnancies in the enquiry are shown in table 5.3. Table 5.3 Outcome of pregnancies in the enquiry No congenital anomaly (N=315) Congenital anomaly (N=127) Total (N=442) Alive at 28 days 220 66 286 Loss before 20 weeks N/A a 19 19 Late fetal loss 13 26 39 Stillbirth 71 6 77 Early neonatal death 9 4 13 Late neonatal death 2 6 8 a Not within defi nition of pregnancies sampled for enquiry Gender was known for 385 of 442 offspring. There were 192 males, 192 females and one indeterminate sex. 5.3.2 Fetal growth restriction Thirty seven babies in the enquiry had documented antenatal evidence of fetal growth restriction or poor growth velocity (table 5.4). Seventy percent (26/37) of these babies had a poor outcome (death and/or fetal congenital anomaly) compared with 50% (222/442) of all babies in the enquiry. There was no difference in the distribution of type of diabetes or ethnicity amongst women whose babies had fetal growth restriction (table 5.4). However, 31% of the women whose babies had antenatal evidence of fetal growth restriction had nephropathy compared to 12% of women in the whole enquiry sample (p=0.002). 20

Table 5.4 Characteristics of women whose babies had antenatal evidence of fetal growth restriction Maternal characteristics Women with antenatal evidence of fetal growth restriction n (%) (N=37) All women in the enquiry n (%) (N=442) Type of diabetes Type 1 26 (70) 324 (73) Type 2 11 (30) 118 (27) Ethnicity White 31 (84) 354 (80) Black 3 (8) 25 (6) Asian 2 (5) 47 (11) Chinese and Other 1 (3) 14 (3) Median maternal age (years) [IQR] 33 [30, 34] 31 [25, 34] Nephropathy 10/32 (31) 42/359 (12) 5.3.3 Macrosomia One hundred and twenty nine babies had documented antenatal evidence of macrosomia (the guidance given to panels was evidence of fetal size greater than the 90th centile for gestational age). Forty one percent (53/129) of these babies had a poor outcome; this was similar to the proportion (50%, 222/442) of all babies in the enquiry having a poor outcome. There was a slightly greater proportion of type 1 diabetes and White ethnicity in women whose babies had antenatal evidence of macrosomia compared to all women in the enquiry sample, but this did not reach significance (p=0.13 and p=0.08 respectively) (table 5.5). Table 5.5 Characteristics of women whose babies had antenatal evidence of macrosomia Maternal characteristics Women with antenatal evidence of fetal macrosomia n (%) a (N=129) All women in the enquiry n (%) (N=442) Type of diabetes Type 1 103 (80) 324 (73) Type 2 26 (20) 118 (27) Ethnicity White 112 (88) 354 (80) Black 7 (5) 25 (6) Asian 6 (5) 47 (10) Chinese and Other 3 (2) 14 (3.2) Maternal age (years) [IQR] 31 [26, 34] 31 [25, 34] Nephropathy 10/102 (10) 42/359 (12) a Percentages are the proportion of women in a category out of the total number of women with a valid response, i.e. excluding ‘not applicable’ and ‘missing’. 21

A description of women and babies <strong>in</strong> <strong>the</strong> enquiry<br />

Table 5.2<br />

Specifi c diabetes complications <strong>in</strong> women <strong>in</strong> <strong>the</strong> enquiry<br />

Specific diabetes complication<br />

Women <strong>in</strong> <strong>the</strong> enquiry<br />

n/N (%)<br />

Recurrent hypoglycaemia dur<strong>in</strong>g <strong>pregnancy</strong> 203/400 (51)<br />

Hypoglycaemia requir<strong>in</strong>g external help 63/311 (20)<br />

Pre-exist<strong>in</strong>g ret<strong>in</strong>opathy 73/316 (23)<br />

New ret<strong>in</strong>opathy 29/316 (9)<br />

Nephropathy 42/359 (12)<br />

5.3 The babies<br />

5.3.1 Pregnancy outcomes<br />

The outcomes of all pregnancies <strong>in</strong> <strong>the</strong> enquiry <strong>are</strong> shown <strong>in</strong> table 5.3.<br />

Table 5.3<br />

Outcome of pregnancies <strong>in</strong> <strong>the</strong> enquiry<br />

No congenital anomaly<br />

(N=315)<br />

Congenital anomaly<br />

(N=127)<br />

Total<br />

(N=442)<br />

Alive at 28 days 220 66 286<br />

Loss before 20 <strong>we</strong>eks N/A a 19 19<br />

Late fetal loss 13 26 39<br />

Stillbirth 71 6 77<br />

Early neonatal death 9 4 13<br />

Late neonatal death 2 6 8<br />

a<br />

Not with<strong>in</strong> defi nition of pregnancies sampled for enquiry<br />

Gender was known for 385 of 442 offspr<strong>in</strong>g. There <strong>we</strong>re 192 males, 192 females and one<br />

<strong>in</strong>determ<strong>in</strong>ate sex.<br />

5.3.2 Fetal growth restriction<br />

Thirty seven babies <strong>in</strong> <strong>the</strong> enquiry had documented antenatal evidence of fetal growth restriction or poor<br />

growth velocity (table 5.4). Seventy percent (26/37) of <strong>the</strong>se babies had a poor outcome (death and/or fetal<br />

congenital anomaly) comp<strong>are</strong>d with 50% (222/442) of all babies <strong>in</strong> <strong>the</strong> enquiry. There was no difference <strong>in</strong><br />

<strong>the</strong> distribution of type of diabetes or ethnicity amongst women whose babies had fetal growth restriction<br />

(table 5.4). Ho<strong>we</strong>ver, 31% of <strong>the</strong> women whose babies had antenatal evidence of fetal growth restriction<br />

had nephropathy comp<strong>are</strong>d to 12% of women <strong>in</strong> <strong>the</strong> whole enquiry sample (p=0.002).<br />

20

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!