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Biosecurity: Status and Policy in Nepal - Center for International and ...

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C-Potential risk of genetically modified<br />

animals & product<br />

I- Adventitious <strong>in</strong>fectious agent transfer<br />

II- Endogenous retroviral activation<br />

III- Entopic expression of transgene (<strong>in</strong> non target tissues)<br />

IV- Excess production of transgene or metabolites<br />

V- Pleiotropic effects of transgene expression (unpredicted<br />

effects on the expression of other genes<br />

VI- Prion disease susceptibility hazards<br />

VII- Leakage of expressed products from target tissues

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