Power Point Slides Alcohol - Meagher Lab

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Maternal Separation Studies Stress causes pups to produce hormones that altered their genes that affects their later behavior, making them less able to cope with stress later in life. The mice exposed to stress have poorer memories, anxiety, and physical health than the control group. Recent research shows how stress in early life could program behavior later in life. The stress causes the animals to produce high levels of stress hormones, and this in turn causes epigenetic changes, meaning that the experience had changed the DNA of a gene coding for the stress hormone vasopressin, which is important in controlling mood and cognitive behaviors, causing the brain developed more vasopressin receptors. Vasopressin involved in social connections such as parent/child bonding but higher levels increase aggressive behavior. The change in the vasopressin gene resulted in the mice being "programmed" to produce high levels of the stress hormone in their adult lives. When the adults were given a drug to block the vasopressin effects, their behavior became more normal… showing the vasopressin change is causal. Dynamic DNA methylation programs persistent adverse effects of early-life stress, Nature Neuroscience, Published online: 8 November 2009; doi:10.1038/nn.2436 Moffett et al 2007. Cruz et al., 2008 Alters drug intake patters in adult rats, increasing self administration of cocaine and alcohol. Implications for human: Explains how trauma in childhood can lead to problems in later life, such as depression and risk of substance abuse. Understanding the molecular basis for the phenomenon lead to new treatments for mental disturbances arising from early stress or trauma. See website for papers.
Prevention of <strong>Alcohol</strong> Abuse ! Legal barriers ! drinking age 21, enforcement, DUI, DWI ! Inoculation programs ! help reduce drunk driving, but work best with light drinkers ! If you catch drinking early, before a heavy use pattern develops, people can control it ! http://www.collegedrinkingprevention.gov/Other<strong>Alcohol</strong>Information/ tipsForCuttingDownonDrinking.aspx#planning
Page 1 and 2: Health-Compromising Behaviors chara
Page 3 and 4: Characteristics of Health-Compromis
Page 5 and 6: What Is Substance Dependence? ! Phy
Page 7 and 8: Addiction Theories (a) The opponent
Page 9 and 10: Opponent Process Theory
Page 11 and 12: B-process grows in strength with re
Page 13 and 14: Koob’ Model (2004) Animal studies
Page 15 and 16: Figure 3 Comparison of the critical
Page 17 and 18: Alcoholism and Problem Drinking: Sc
Page 19 and 20: DSM-IV Definitions ! ALCOHOL ABUSE:
Page 21 and 22: EPIDEMIOLOGY ! Stats: ! 1 out of 10
Page 23 and 24: High School Alcohol Use 80% of 12th
Page 25 and 26: Prevalence of alcohol use and depen
Page 27 and 28: Epidemiology ! Personality factors
Page 29 and 30: Physiological Aspects of Alcohol Co
Page 31 and 32: How alcohol affects the brain
Page 33 and 34: J-Shaped Curves J-shaped associatio
Page 35 and 36: Alcohol and all cause mortality The
Page 37 and 38: Alcohol:Incidence of Diabetes II Al
Page 39 and 40: Alcoholism and Problem Drinking: Is
Page 41 and 42: Heavy Drinking and Health ! Alcohol
Page 43 and 44: Women More Vulnerable? Women are mo
Page 45 and 46: Alcoholism and Problem Drinking: Or
Page 47: Gene Environment Interactions ! Ear
Page 51 and 52: Alcoholism and Problem Drinking: Dr
Page 53 and 54: Alcoholism and Problem Drinking: Th
Page 55 and 56: Alcoholism and Problem Drinking: Tr
Page 57 and 58: Psychological Treatments ! Insight
Page 59 and 60: Inpatient treatment? Evidence sugge
Page 61 and 62: Motivational Enhancement Therapy 4)
Page 63 and 64: Alcoholism and Problem Drinking: Pr
Page 65 and 66: AA ! Dropout rate unknown? ! Compar
Page 67 and 68: PROJECT MATCH ! Compared 3 manualiz
Page 69 and 70: Alcoholism and Problem Drinking: Tr
Page 71: Alcoholism and Problem Drinking: Tr

Power Point Slides Alcohol - Meagher Lab

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