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Power Point Slides Alcohol - Meagher Lab

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<strong>Alcohol</strong>ism and Problem Drinking:<br />

Origins<br />

! Genetic factors appear to be involved<br />

! Twins studies<br />

! if one twin is alcoholic, the likelihood that the other<br />

twin is alcoholic is 2 times as high if identical (54%) vs.<br />

fraternal (28%), relationship not always this strong<br />

! genetics=20% of the variance some studies, 50% others<br />

! What is inherited? GABA, serotonin gene that regs<br />

dopamine receptors? Early environment?<br />

! Frequency of alcoholism in sons of alcoholics<br />

! Men traditionally were at greater risk<br />

! With changing norms, women are “catching up”<br />

! Multifactorial: Physiological, behavioral, and<br />

sociocultural factors are involved

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