Power Point Slides Alcohol - Meagher Lab

Power Point Slides Alcohol - Meagher Lab Power Point Slides Alcohol - Meagher Lab

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25.10.2014 Views

Robinson & Berridge Model 30 ROBINSON ⌅ BERRIDGE Figure 2 Adaptation of Figure 4 (panel B) in Koob & Le Moal (1997, p. 56), in which they depict sensitization as amplifying the hedonic a-process. They state that this panel shows an “affective stimulus in an individual with an intermittent history of drug use that may result in sensitized response. The shaded line illustrates ...the initial experience. The dotted line represents the sensitized response” (p. 56). Note that sensitization is hypothesized to increase the hedonic A-state by this view, which would be experienced as enhanced drug pleasure.

Figure 3 Comparison of the critical change in addiction leading to compulsive drug pursuit according the stimulus-response (S-R) habit learning hypothesis (left) and the incentivesensitization hypothesis (right). According to the S-R habit learning model addiction (compulsive drug pursuit) is primarily due to the development of very strong S-R habits [indicated by the thick arrow from a drug cue (CS) to a response (drug pursuit)]. According to the incentive-sensitization view the critical change is in the ability of representations of drug cues (the dashed US evoked by a drug cue) to engage a sensitized motivational response of incentive salience (as indicated by the starburst). This enhanced motivational response is primarily responsible for compulsive drug pursuit (thick arrow) in addiction according to our view.

Figure 3 Comparison of the critical change in addiction leading to compulsive drug pursuit<br />

according the stimulus-response (S-R) habit learning hypothesis (left) and the incentivesensitization<br />

hypothesis (right). According to the S-R habit learning model addiction (compulsive<br />

drug pursuit) is primarily due to the development of very strong S-R habits [indicated<br />

by the thick arrow from a drug cue (CS) to a response (drug pursuit)]. According to the<br />

incentive-sensitization view the critical change is in the ability of representations of drug<br />

cues (the dashed US evoked by a drug cue) to engage a sensitized motivational response<br />

of incentive salience (as indicated by the starburst). This enhanced motivational response is<br />

primarily responsible for compulsive drug pursuit (thick arrow) in addiction according to our<br />

view.

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