Proton Pump Inhibitors - CME Conferences

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6 th Annual Primary Care Spring Conference Thursday, April 12, 2012 Avoid Use of Glyburide? In-hospital mortality in patients on sulfonylureas before admission (n = 459) according to the type of sulfonylureas and stratified by specific subgroups (J Clin Endocrinol Metab, November 2010, 95(11):4993–5002) UK Prospective Diabetes Study Glucose Interventional Trial Dietary Run-in 744 Diet failure FPG >15 mmol/l Randomisation 1977-1991 2,729 Intensive with sulfonylurea/insulin Trial end 1997 Intensive P 5,102 Newly-diagnosed type 2 diabetes 4209 1,138 (411 overweight) Conventional with diet Conventional P 149 Diet satisfactory FPG
6 th Annual Primary Care Spring Conference Thursday, April 12, 2012 Any Diabetes Related Endpoint (%) at 10 years • Diet + Metformin 28.7% • Diet + Sulf/Insulin 36.8% • Diet only 38.9% • RRR 26.2% with diet + metformin vs. diet alone • ARR 10.2% • NNT 10 All Cause Mortality (%) at 10 years • Diet + Metformin 14.6% • Diet + Sulf/Insulin 20% • Diet alone 21.7% • RRR 32.7% with metformin + diet vs. diet alone • ARR 7.1% • NNT 14 Wayne Weart, Pharm D Cost Effective Rx
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