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Proton Pump Inhibitors - CME Conferences

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6 th Annual Primary Care Spring Conference Thursday, April 12, 2012<br />

Avoid Use of Glyburide?<br />

In-hospital mortality in patients on sulfonylureas before admission (n = 459) according to the type of<br />

sulfonylureas and stratified by specific subgroups (J Clin Endocrinol Metab, November 2010, 95(11):4993–5002)<br />

UK Prospective Diabetes Study<br />

Glucose Interventional Trial<br />

Dietary<br />

Run-in<br />

744<br />

Diet failure<br />

FPG >15 mmol/l<br />

Randomisation<br />

1977-1991<br />

2,729<br />

Intensive<br />

with sulfonylurea/insulin<br />

Trial end<br />

1997<br />

Intensive<br />

P<br />

5,102<br />

Newly-diagnosed<br />

type 2 diabetes<br />

4209<br />

1,138 (411 overweight)<br />

Conventional<br />

with diet<br />

Conventional<br />

P<br />

149<br />

Diet satisfactory<br />

FPG

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