Proton Pump Inhibitors - CME Conferences
Proton Pump Inhibitors - CME Conferences
Proton Pump Inhibitors - CME Conferences
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
6 th Annual Primary Care Spring Conference Thursday, April 12, 2012<br />
<strong>Proton</strong> <strong>Pump</strong> <strong>Inhibitors</strong><br />
AGA Technical Review 2008<br />
• Ample evidence that PPIs are more effective<br />
than H2RAs in patients with esophageal GERD<br />
syndromes<br />
• Data supporting PPI doses higher than<br />
standard are minimal<br />
• There is no evidence that adding a nocturnal<br />
dose of an H2RA to twice daily PPI therapy<br />
improves long-term efficacy<br />
• Gastroenterology 2008;135:1392-1413<br />
<strong>Proton</strong> <strong>Pump</strong> <strong>Inhibitors</strong><br />
• A Cochrane review of 134 treatment trials in 36,978<br />
patients with esophagitis, concluded that PPIs exhibit a<br />
better healing effect and faster symptom relief then<br />
H2RAs which in turn are better than placebo<br />
• concluded that there is no major difference in<br />
efficacy among the currently available PPIs<br />
(esomeprazole, lansoprazole, omeprazole,<br />
pantoprazole, rabeprazole)<br />
• the gain achieved by doubling the standard dose of<br />
PPI therapy is modest.<br />
• Cochrane Database Syst Rev 2007;2:CD003244<br />
Wayne Weart, Pharm D<br />
Cost Effective Rx
Change language