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Proton Pump Inhibitors - CME Conferences

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6 th Annual Primary Care Spring Conference Thursday, April 12, 2012<br />

American Academy of Neurology<br />

Consensus Statement<br />

“ Nonequivalence can have very serious<br />

effects. Decreased serum drug<br />

concentrations can cause breakthrough<br />

seizures, and increased concentrations<br />

can lead to toxicity……The overall cost<br />

to society of breakthrough seizures or<br />

drug toxicity may outweigh any<br />

economic incentive for mandating<br />

generic substitution”<br />

Neurology 1990;40:1647-1651<br />

FDA<br />

FDA Estimate of Savings<br />

Center for Drug Evaluation and Research<br />

Wayne Weart, Pharm D<br />

Cost Effective Rx

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