CURRICULUM VITAE - University of Sulaimani

CV: Beston Nore – December 2010 Page 1
CURRICULUM VITAE
First-, Middle-, Last Name: BESTON FAIEK NORE
Academic Degree: BSc, PhD, Assistant Professor
Academic Position: Head of Biochemistry Department
Email: beston.nore@univsul.net
Telephone: +964-770 770 6628 or +964-750 325 55 60
A. EDUCATION & ACADEMIC POSITIONS / QUALIFICATIONS
July 1979: Awarded BSc degree in General Chemistry at Sulaimani University.
June 1981: Laboratory assistance, Department of Chemistry, College of Sciences, at Sulaimani
University.
October 1985: Awarded MSc degree “Bioenergetics” in Biochemistry at Stockholm University. Project
title: “Studies on inorganic pyrophosphate synthesis by continuous illumination and by short light flash
in Rhodospirillum rubrum chromatophores”.
September 1990: Awarded PhD degree “Bioenergetics” in Biochemistry at Stockholm University. Title
of Doctoral Dissertation: “ Protonmotive coupling of energy conversion processes in photosynthetic
bacteria – Studies on membrane energization and phosphorylation capacity. Supervisor: Professor
Margareta Baltscheffsky.
1991-1993: Postdoctoral Research Fellow, Department of Plant Cell Biology, Oslo University, Norway.
1994-1995: Postdoctoral Research Fellow, Department of Plant Biology, Royal Veterinary and
Agricultural University, Copenhagen, Denmark.
1996-2010: Senior Research Scientist at Karolinska Institutet (KI), Novum Research Park.
2003-2006: Study Director for the postgraduate study program "Cell and Molecular Biology", at the
Department of Clinical Research Centre.
2006-2010: Study director and head for the postgraduate study program "Developmental Biology and
Cellular Signalling (DECS)" at Karolinska Institutet.
Since 2004: Associate Professor - Cellular Biochemistry at Karolinska Institutet.
Since 2009: Assistant Professor – Head of the Biochemistry Department, College of Medicine, at
University of Sulaimani.
B. ACADEMIC DUTIES (PREVIOUS AND CURRENT)
(1) Supervision, Board member and Mentorship for High Diploma, Kurdistan Medical Board, Clinical
Biochemistry MSc Board, PhD students inside and outside of Kurdistan. (2) Organizing PhD courses
and also extensive teaching duties (undergraduate and postgraduate level), approximately 240 hours
per academic year. (3) Previous administration as the Head of postgraduate program DECS at
Karolinska Institutet, approximately 120 hours per academic year. Current administration as the Head
of Biochemistry Department, Medical College, University of Sulaimani, (4) Grant applications for a
number of research proposals inside and outside Kurdistan. (5) Establishing international link for
research and cooperation on various levels between University of Sulaimani, Sulaimani Health
Directorate and Strategic Research Facilities in Sulaimani together with international academic centres
and Universities. (6) Editing scientific reports, research proposals, research articles and manuscripts for
various journals and governmental authorities.
C. SUPERVISION OF MSc, PhD & POSTDOCTORAL RESEARCHER (between 2007-2011 only)
Period Level Percentage (%) Names and Affiliation
2001-2007 PhD 100 % Juhana Heinonen – Karolinska Institutet
2004 MSc 100 % Nina Grankvist – Södertörn University College

CV: Beston Nore – December 2010 Page 2
2006 MSc 100 % John Heron - Södertörn University College
2006 PhD 50 % Jorge Lozano – University of Chile, Chile
2007-2008 Postdoctoral 50 % Rani Faryal Faheem – Karolinska Institutet
2007 - PhD 25 % Alamdar Baloch – Karolinska Institutet
2007- PhD 25 % Noriko Hamada – Tohoku University, Japan
2008- PhD 100 % Manuela Gustafsson - Karolinska Institutet
2008-2010 PhD 50 % Ban Rasheed – Sulaimani University
2010 MSc 100 % Hedley K. Quintana -Södertörn University College.
2011- MSc/PhD 100 % New students from University of Sulaimani.
D. EXAMINATION COMMITTEE FOR MASTER (MSc) & DOCTORAL (PhD) DISSERTATIONS
2006-2009 2 MSc (thesis) Yunling Wang and Zhengwen An at KI.
2008-2009 3 PhD (thesis) Anders Rehn (KI), Patrik Müller (KI) and Kristina Masson (Lund).
2010-2011 3 MSc/PhD (thesis) at Sulaimani University.
E. INVITED SPEAKER (about 25 lectures since 1998)
Topics: Bioenergetics, Protein Phosphorylations, Tyrosine kinases, RNA interference, Proteomics,
Cellular Signalling (Japan, USA, Canada, UK, Germany, Sweden, Norway, Pakistan, UAE and
Kurdistan-Iraq).
F. ORGANIZING COMMITTEE FOR SCIENTIFIC WORKSHOP & CONGRESS
1992 - VIIIth International Congress on Photosynthesis, Stockholm.
1997- 8th international Centre for Biotechnology (CBT) Symposium.
1999-2003 Organizer for Novum Minisymposium on Cellular Signalling (once per year).
G. . LIIST OF PUBLIICATIIONS
1. Nore B.F., Husain I., Nyrén P. & Baltscheffsky M. (1986) "Synthesis of pyrophosphate coupled to the reverse energy-linked
transhydrogenase reaction in Rhodospirillum rubrum chromatophores". FEBS Lett. 200 : 133-138.
2. P. Nyrén, B.F. Nore & M. Baltscheffsky (1986) 4th European Bioenergetics Conference, pp. 129.
3. Nyrén P., Nore B.F. & Baltscheffsky M. (1986) "Studies on photosynthesis inorganic pyrophosphate formation in
Rhodospirillum rubrum chromatophores". Biochim. Biophys. Acta 851 : 276-282.
4. B.F. Nore, I. Husain, P. Nyrén & M. Baltscheffsky (1986) 4th European Bioenergetics Conference, pp. 327.
5. Nyrén P., Nore B.F. & Baltscheffsky M. (1986) "Inorganic pyrophosphate synthesis after a short light flash in chromatophores
from Rhodospirillum rubrum". Photobiochem. Photobiophys. 11 : 189-196.
6. I. Husain, B.F. Nore, P. Nyrén & M. Baltscheffsky (1986) VIIth Int. Congr. on Photosynthesis, pp. 108-A.
7. P. Nyrén, B.F. Nore & M. Baltscheffsky (1986) 17th FEBS Meeting, West Berlin, Biol. Chem. Hoppe-Seyler 367,144.
8. Strid Å., Nore B.F., Nyrén P. & Baltscheffsky M. (1987) "Diethylstilbestrol is an inhibitor of the H + -PPase but not of the H + -
ATPase of Rhodospirillum rubrum chromatophores". Biochim. Biophys. Acta 892 : 236-244.
9. B.F. Nore, M. Welch & M. Baltscheffsky (1988) Directions in Bioscience- a Swedish-Finish-American Conference, group 6:
Bioenergetics.
10. B.F. Nore (1988) 5th European Bioenergetics Conference, pp. 107.
11. B.F. Nore, T.M. Lever, N.P.J. Cotton, M.R. Jones & J.B. Jackson (1988) 5th European Bioenergetics Conference, pp. 106.
12. B.F. Nore, P. Nyrén & Å. Strid (1988) Techniques & New Development in Photosynthesis, pp. 34.
13. B.F. Nore, T.M. Lever, N.P.J. Cotton, M.R. Jones & J.B. Jackson (1988) Techniques & New Development in Photosynthesis,
pp. 33.
14. Cotton N.P.J., Lever T.M., Nore B.F., Jones M.R. & Jackson J.B. (1989) "The coupling between protonmotive force & the
NAD(P) + transhydrogenase in chromatophores from photosynthetic bacteria". Eur. J. Biochem. 182 : 593-603.
15. M. Baltscheffsky, B.F. Nore, P. Nyrén & Å. Strid (1989) International symposium on Regulation &
Efficiency of Photosynthesis, pp. 20.
16. P. Nyrén, B.F. Nore, G.F. Salih & Å Strid (1989) VIIIth Int. Congr. on Photosynthesis, Physiol. Plant. 76, pp. A-20.
17. Y. Sakai, B.F. Nore & M. Baltscheffsky (1989) VIIIth Int. Congr. on Photosynthesis, Physiol. Plant. 76, pp. A-160.
18. Nore B.F.(1989) "∆pH driven energy-linked NAD + reduction in Rhodospirillum rubrum chromatophores". Arch. Biochem.
Biophys. 274 : 285-289.
19. Nore B.F., Cotton N.P.J., Lever T.M., Jones M.R. & Jackson J.B. (1989) "Energy coupling to Pyridine Nucleotide
transhydrogenase in chromatophores from photosynthetic bacteria". In Techniques & New Developments in
Photosynthesis Research (J. Barber & R. Malkin, eds), vol. 168 : 285-286, Plenum Press, New York.
20. Nore B.F., Nyrén P., Salih G.F. & Strid Å. (1990) "Photosynthetic formation of inorganic pyrophosphate in phototrophic
bacteria ". Photosynth. Res. 24 : 75-80.
21. Y. Sakai-Nore, B.F. Nore & M. Baltscheffsky (1990) Electrified Interfaces in Physics Chemistry and Biology, pp. 45.
22. Nore B.F., Sakai Y. & Baltscheffsky M. (1990) "Comparison of the contribution from different energy-linked reactions to the
function of a membrane potential in photosynthetic bacteria". Biochim. Biophys. Acta. 1015 : 189-194.
23. Nore B.F. (1990) "Protonmotive coupling of energy conversion processes in photosynthetic bacteria-studies on membrane
energization and phosphorylation capacity". Ph.D. Thesis , University of Stockholm.
24. B.F. Nore, P. Nyrén & Y. Sakai-Nore (1990) Electrified Interfaces in Physics Chemistry and Biology, pp. 46.
25. Nore B.F., Sakai Y. & Baltscheffsky M. (1990) "Generation of membrane potential from different energy-linked reactions in
photosynthetic bacteria". In Current Research in Photosynthesis, (M. Baltscheffsky, ed.), vol. III, pp. 205-208. Kluwer
Academic Publishers, The Netherlands.
26. Nyrén P., Nore B.F., Salih G.F. & Strid Å. (1990) "Light-driven inorganic pyrophosphate synthesis in phototrophic bacteria".
In Current Research in Photosynthesis, (M. Baltscheffsky, ed.), vol. III, pp. 23-28. Kluwer Academic Publishers, The

CV: Beston Nore – December 2010 Page 3
Netherlands.
27. Nyrén P., Nore B.F. & Strid, Å. (1991) "Proton pumping DCCD-sensitive inorganic pyrophosphatase from Rhodospirillum
rubrum : Purification, characterization and reconstitution". Biochemistry 30 : 2883-2887.
28. B.F. Nore, N.F. Tsinoremas, M.A. Harrison, C.A. Allen & J.F. Allen (1991) Physiologia Plantarum 82(3): B15.
29. B.F. Nore, N.F. Tsinoremas, M.A. Harrison, C.A. Allen & J.F. Allen (1991) The molecular and structural basis of regulation in
photosynthesis, pp. 60.
30. B.F. Nore, M.A. Harrison, B.A. Andersson & J.F. Allen (1991) First Nordic Congress on Photosynthesis, pp. 11.
31. Nore B.F., Sakai-Nore Y., Maeshima M., Baltscheffsky M. & Nyrén, P. (1991) "Immunological cross-reactivity between
proton-pumping inorganic pyrophosphatase of widely phylogenic separated species". Biochem. Biophys. Res. Commun.
181 : 962-967.
32. B.F. Nore, M.A. Harrison, B.A. & J.F. Allen (1992) IX Int. Congr. on Photosynthesis, Physiol. Plant. 82, pp. 460.
33. Nore B.F., Harrison M.A. & Allen J.F. (1992) "Purification of the 15 kDa phosphoprotein of Synechococcus 6301". In
Research in Photosynthesis (Murata, N., ed.), vol. IV, pp. 345-348, Kluwer Academic Publishers, The Netherlands.
34. B.F. Nore, M.A. Harrison, B.A. & J.F. Allen (1993) 22nd FEBS Meeting, pp. 174.
35. B.F. Nore (1993) Second Nordic Congress on Photosynthesis, pp. 62.
36. Nore B.F., Harrison M.A., Keen J.N. & Allen J.F. (1994) "Partial purification of a cyanobacterial thylakoid-membrane protein
with the N-terminal sequence as the N-methylohenylalanine pilins". Acta Chemica Scandinavica 48 : 578-581.
37. Vihinen M., Nore B.F., Mattsson P.T., Bäckesjö C-M., Nars M., Koutaniemi S., Watanabe C., Lester T., Jones A., Ochs H.D. &
Smith C.I.E. (1997) "Missense mutations affecting a conserved cysteine pair in the TH domain of Btk". FEBS Lett. 413 : 205-
210.
38. C.I.E. Smith, P.T. Mattsson, H. Hansson, P. Allard, S. Müller, P. Sideras, K. Xanthopoulos, C.M. Bäckesjö, B.F. Nore, H.D. Ochs,
T. Härd & M. Vihinen (1997) Ketstone Symposia on Molecular and Cellular Biology: B Lymphocytes in Health and Disease,
pp. 49.
39. C.I.E. Smith, P.T. Mattsson, H. Hansson, P. Allard, C.M. Bäckesjö, B.F. Nore, T. Härd & M. Vihinen (1997) Keystone Symposia
on Molecular and Cellular Biology: Temporal and Spatial Determinations of Specificity in Signal Transduction, pp. 38.
40. C.M. Bäckesjö, B.F. Nore, E. Holinski-Feder, M. Vihinen, P.T. Mattsson, A. Meindl, M. Weiss & C.I.E. Smith (1997) 8th
International center for Biotechnology Symposium on Cytoplasmic Protein-Tyrosine Kinases, pp. 50.
41. B.F. Nore, C.M. Bäckesjö, M. Vihinen, P.T. Mattsson, H.D. Ochs, B. Christensson & C.I.E. Smith (1997) FEBS Special Meeting:
Cell Signaling Mechanisms from Membrane to Nucleus, P4-068.
42. B.F. Nore, M. Bäckesjö, M. Vihinen, P.T. Mattsson, H.D. Ochs, B. Christensson & C.I.E. Smith (1997) The Wenner-Gren
Symposium on Protein Phosphorylation, pp. 33.
43. C.M. Bäckesjö, M. Mattsson, B.F. Nore, E. Holinski-Feder, M. Weiss, M. Vihinen, A. Meindl & C.I.E. Smith (1997) The Wenner-
Gren Symposium on Protein Phosphorylation, pp. 2.
44. M. Vihinen, P.T. Mattsson, H. Hansson, P. Allard, M. Bäckesjö, B.F. Nore, Sanna Koutaniemi, P. Haapaniemi, T. Härd & C.I.E.
Smith (1997) The Wenner-Gren Symposium on Protein Phosphorylation, pp. 46.
45. Holinski-Feder E., Weiss M., Brandau O., Jedele K.B., Nore B.F., Bäckesjö C.M., Vihinen M., Götz G., Hubbard S.R.,
Belohradsky B.H., Smith, C.I.E. & Meindl A. (1998) "Mutation screening of the BTK gene in 56 families with X-linked
agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course". Pediatrics 101 : 276-284.
46. Smith C.I.E., Bäckesjö C-M., Berglöf A., Brandén L., Islam T., Mattsson P.T., Mohamed A.J., Müller S., Nore B.F. & Vihinen M.
(1998) " X-linked agammaglobulinemia. Lack of mature B lineage cells caused by mutations in the Btk kinase". Springer
Semin. Immunopathol. 19 : 369-381.
47. Mohamed A.J., Nore B.F., Christensson B. & Smith C.I.E. (1999) “Signaling of Bruton’s tyrosine kinase, Btk”. Scand. J.
Immunol. 49 : 113-188.
48. Mohamed A.J., Vargas L., Nore B.F., Bäckesjö C-M, Christensson B. & Smith C.I.E. (2000) “Nucleocytoplasmic shuttling of
Bruton’s tyrosine kinase”. J Biol Chem 275 : 40614-40619.
49. Nore B.F., Mohamed A.J., Vargas L., Brandén L., Bäckesjö C-M., Vihinenn M., Christensson B. & Smith C.I.E. (2000) "The role
of Bruton’s tyrosine kinase (Btk) in phophoinositide-dependent signaling”. Allergy Clin. Immunol. Int. 12 : 126-133.
50. Nore B.F., Vargas L., Mohamed A.J., Brandén L., Bäckesjö C-M., Islam T., Mattsson P.T., Hultenby K., Christensson B. & Smith
C.I.E. (2000) "Redistribution of Btk family tyrosine kinases by activation of phosphatidylinositol-3-kinase and Rho family
GTPases". Eur. J. Imunol. 30 : 145-154.
51. C.I.E. Smith, B.F.. Nore, L. Vargas, A.J. Mohamed, L. Brandén, C.M. Bäckesjö, T. Islam, P.T. Mattsson, K. Hultenby, & B.
Christensson (2000) Keystone Symposia: Signaling 2000, pp. 115.
52. Smith C.I.E., Islam T.C., Mattsson P.T., Mohamed A.J., Nore B.F. & Vihinen M. (2001) "The Tec family of cytoplasmic tyrosine
kinases: mammalian Btk, Bmx, Tec, Txk and homologs in other species". BioEssays 23 : 436-446.
53. Vargas L., Nore B.F., Berglöf A., Heinonen J.E., Mattsson P.T., Smith C.I.E. & Mohamed A.J. (2002) “Functional interaction of
Caveoline-1 with Bruton’s Tyrosine kinase and Bmx” J. Biol. Chem. 277 : 9351-9357.
54. Signaling of Bruton’s tyrosine kinase. Abstract: Proceedings of Cell signaling, transcription and translation as therapeutic
targets, Luxemburg (2002) J.E. Heinonen, B.F. Nore, A.J. Mohamed, P.T. Mattsson and C.I.E. Smith, pp. 22
55. Heinonen J.E., Smith C.I.E. & Nore B.F. (2002) “Silencing of Bruton’s tyrosine kinase (Btk) using short interfering RNA
duplexes (siRNA)” FEBS Lett. 527: 274-278.
56. siRNA Approach to Study Btk-related Signaling in Hematopoietic Cells. Poster and Abstract TIGR's 14th international
Genome Sequencing and Analysis Conference, Boston USA (2002) J.E. Heinonen, C.I.E. Smith, B.F. Nore, pp. 33
57. Signaling of Bruton’s tyrosine kinase. Abstract: Proceedings of Cell signaling, transcription and translation as therapeutic
targets, Luxemburg (2002) J.E. Heinonen, B.F. Nore, A.J. Mohamed, P.T. Mattsson and C.I.E. Smith, pp. 22
58. Modulation in the signalsome assembly of Bruton’s tyrosine kinase (Btk), FEBS special meeting in Brussels (2003) B.F. Nore,
J.E. Heinonen and C.I.E. Smith, pp 197.
59. Heinonen J.E., Mohamed A.J., Nore B.F. & Smith C.I.E. (2005) “Inducible H1 promoter-driven lentiviral siRNA expression by
stuffer reporter deletion” Oligonucleotide 15: 139-144.
60. Lindvall J.M., Blomberg K.E.M., Väliaho J., Vargas L., Heinonen J.E., Berglöf A., Mohamed A.J., Nore B.F., Vihinen M., & Smith
C.I.E. (2005) “Btk- cell biology, sequence conservation, mutation spectrum, siRNA modifications and expression profiling”
Immunol Rev 203: 200-215.
61. Yu L., Mohamed A.J., Simonson O.E., Vargas L., Blomberg K.E.M., Björkstrand B., Arteaga H.J., Nore B.F. & Smith C.I.E. (2008)
“Proteasome-dependent autoregulation of Bruton’s Tyrosine Kinase (Btk) Promoter via NF-kB” Blood 111: 4617-26.
62. Ortutay C., Nore B.F., Vihinen M. & Smith C.I.E. (2008) ”Phylogy of Tec family kinases: Identification of Pre-Metazoan
Ancestry and the origin of Btk, Bx, Itk, Tec, Txk/[Rlk] and the Btk regulator SH3BP5” Advances in Genetics 64: 51-80.
63. Mohamed A.J., Yu L., Bäckesjö C.M., Aints A., Christensson B., Berglöf A., Vihinen M., Nore B.F. & Smith C.I.E. (2009)
“Bruton´s Tyrsone Kinase (Btk) – function, regulation and transformation with special emphasis on the PH domain”

CV: Beston Nore – December 2010 Page 4
Immunol Rev 228: 58-73.
64. Hussain A., Faryal R., Nore B.F., Mohamed A.J. & Smith C.I.E. (2009) “Phosphatidylinositol-3-kinase-dependent
Phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein” BBRC 390: 892-896.
65. Hamada-Kawaguchi N., Nore B.F., Smith C.I.E. & Yamamoto D. (2010) “Btk-mediated tyrosine phosphorylationof β-catenin
gates BMP-signaling in the stem cell niche” Science, submitted.
66. Gustafsson M.O., Alamdar H., Mohamed A.J., Paswson T., Smith C.I.E. & Nore B.F. (2010) “ANKRD54/Liar, a novel ankryin
repeat protein, prevents nucleo/cytoplasmic shuttling of Bruton´s tyrosine kinase (Btk)” Blood, submitted.
67. Herron J. & Nore B.F. (2010) “Viral Transduction, a method for proteomic research to identify protein-protein interactions”
Kurdistan Academicians Journal 7-8, part A, 63-77.
68. Lozano J., Muñoz P., Nore B.F., LeDoux and Segura-Aguilar J. (2010) “Stable expression of short interfering RNA for DT-
Diaphorase induces neurotoxicity” Chem. Res. Toxicol 23, 1492-1496.
69. Hussain, Alamdar; Yu, Liang; Faryal, Rani; Mohammad, Dara; Mohamed, Abdalla; Nore, F. Beston Smith, C. I. Edvard (2011)”
TEC-family kinases in health and disease: Loss-of-function of BTK and ITK and the gain-of function fusions ITK-SYK and
BTK-SYK” FEBS Lett., in press.
H. TEACHING QUALIFICATIONS
1985-1990 Teaching (Theory and Laboratory training) (200 h per academic year) as
Laboratory Assistant for Basic Biochemistry Courses, Dept. of Biochemistry at
Stockholm University.
1991-1994 Lecturing (Theory) on the topic "Cell Bioenergetics" (6 h per academic year) for
C-level Biochemistry Courses.
1997 Lecturing (Theory and Laboratory training) on the topic "Cell Communications
and secondary messengers" (18 h per academic year) for the Molecular Cell
Biology Course at Södertörn University College.
1998-2009 Lecturing (Theory and Laboratory training) on the topic "cytoplasmic tyrosine
kinases, signaling proteins and domains and phosphoinositol signaling" (34 h per
academic year) in the Cell Communication and Signaling Course, Södertörn
University College.
1999-2011 Organizing (once per year) of the Postgraduate Course “Cellular Signaling” (1
point) for PhD students at KI (course code # 1280). (One week for leading the
course 40 h; lecturing part 8 h). Administration time in organizing and planning the
course is 80 h minimum per academic year.
2000-2001 Lecturing (Theory) on the topic “signal transduction of non-receptor tyrosine
kinases” (10 h per academic year; 1 h teaching and 9 h for PBL-training
supervision), Stockholm graduate school of Biomedical research (Biomedical
forskarskola).
2003-2011 Course leader and organizer (once every other year) (4 weeks per occasion)
“Kliniskt Forskarskola i molekylärmedicin" or “Advanced Research School in
Molecular Medicine for Clinicians” Karolinska Institutet and Huddinge University
Hospital”. (80 h leading and active guidance of the course).
2009-2011 Undergraduate and postgraduate course within Clinical Biochemistry and
Molecular Diagnostics at College of Medicine, University of Sulaimani.