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European Resuscitation Council Guidelines for Resuscitation 2010 ...

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1258 J.P. Nolan et al. / <strong>Resuscitation</strong> 81 (<strong>2010</strong>) 1219–1276<br />

Cardiac arrest associated with pregnancy<br />

Mortality related to pregnancy in developed countries is rare,<br />

occurring in an estimated 1:30,000 deliveries. 667 The fetus must<br />

always be considered when an adverse cardiovascular event occurs<br />

in a pregnant woman. <strong>Resuscitation</strong> guidelines <strong>for</strong> pregnancy are<br />

based largely on case series, extrapolation from non-pregnant<br />

arrests, manikin studies and expert opinion based on the physiology<br />

of pregnancy and changes that occur in normal labour.<br />

Studies tend to address causes in developed countries, whereas<br />

the most pregnancy-related deaths occur in developing countries.<br />

There were an estimated 342,900 maternal deaths (death during<br />

pregnancy, childbirth, or in the 42 days after delivery) worldwide<br />

in 2008. 668<br />

Causes of cardiac arrest in pregnant women include: cardiac<br />

disease; pulmonary embolism; psychiatric disorders; hypertensive<br />

disorders of pregnancy; sepsis; haemorrhage; amniotic fluid<br />

embolism; and ectopic pregancy. 669 Pregnant women can also sustain<br />

cardiac arrest from the same causes as women of the same age<br />

group.<br />

Modifications to BLS guidelines <strong>for</strong> cardiac arrest during<br />

pregnancy<br />

After 20 weeks’ gestation, the pregnant woman’s uterus can<br />

press down against the inferior vena cava and the aorta, impeding<br />

venous return and cardiac output. Uterine obstruction of venous<br />

return can cause pre-arrest hypotension or shock and, in the critically<br />

ill patient, may precipitate arrest. 670,671 After cardiac arrest,<br />

the compromise in venous return and cardiac output by the gravid<br />

uterus limits the effectiveness of chest compressions.<br />

The key steps <strong>for</strong> BLS in a pregnant patient are:<br />

• Call <strong>for</strong> expert help early (including an obstetrician and neonatologist).<br />

• Start basic life support according to standard guidelines. Ensure<br />

good quality chest compressions with minimal interruptions.<br />

• Manually displace the uterus to the left to remove caval compression.<br />

• Add left lateral tilt if this is feasible—the optimal angle of tilt is<br />

unknown. Aim <strong>for</strong> between 15 and 30 ◦ . The angle of tilt needs<br />

to allow good quality chest compressions and if needed allow<br />

caesarean delivery of the fetus (see below).<br />

Modifications to advanced life support<br />

There is a greater potential <strong>for</strong> gastro-oesophageal sphincter<br />

insufficiency and risk of pulmonary aspiration of gastric contents.<br />

Early tracheal intubation with correctly applied cricoid pressure<br />

decreases this risk. Tracheal intubation will make ventilation of<br />

the lungs easier in the presence of increased intra-abdominal<br />

pressure. A tracheal tube 0.5–1 mm internal diameter (ID) smaller<br />

than that used <strong>for</strong> a non-pregnant woman of similar size may be<br />

necessary because of maternal airway narrowing from oedema<br />

and swelling. 672 There is no change in transthoracic impedance<br />

during pregnancy, suggesting that standard shock energies <strong>for</strong><br />

defibrillation attempts should be used in pregnant patients. 673<br />

Rescuers should attempt to identify common and reversible<br />

causes of cardiac arrest in pregnancy during resuscitation attempts.<br />

The 4Hs and 4Ts approach helps identify all the common causes<br />

of cardiac arrest in pregnancy. Pregnant patients are at risk of all<br />

the other causes of cardiac arrest <strong>for</strong> their age group (e.g., anaphylaxis,<br />

drug overdose, trauma). Consider the use of abdominal<br />

ultrasound by a skilled operator to detect pregnancy and possible<br />

causes during cardiac arrest in pregnancy; however, do not delay<br />

other treatments.<br />

If immediate resuscitation attempts fail<br />

Consider the need <strong>for</strong> an emergency hysterotomy or caesarean<br />

section as soon as a pregnant woman goes into cardiac arrest. In<br />

some circumstances immediate resuscitation attempts will restore<br />

a perfusing rhythm; in early pregnancy this may enable the pregnancy<br />

to proceed to term. When initial resuscitation attempts fail,<br />

delivery of the fetus may improve the chances of successful resuscitation<br />

of the mother and fetus. 674–676<br />

• At gestational age

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